Department of Pathophysiology, National Koranyi Institute for TB and Pulmonology, Budapest, Hungary.
Int J Biol Markers. 2010 Jan-Mar;25(1):52-6.
Exhaled breath condensate (EBC) analysis is a promising method for investigating airway pathology. In this study we compared the cytokine pattern of EBC of patients suffering from squamous cell lung carcinoma with that of healthy smokers. Breath condensates collected from 8 smoking lung cancer patients before receiving any anticancer treatment and 8 smokers without any clinical or radiological evidence of pulmonary tumors were used for antibody microarray analysis testing 120 cytokines simultaneously. Ninety-eight cytokines on the array gave a detectable signal in both groups. Cytokine levels were similar across the samples, and none of the cytokines exhibited a significant increase or decrease in cancer patients as compared to healthy subjects with similar smoking status, lung function, and airway inflammation. The results of this pilot study suggest that patients with squamous cell lung carcinoma cannot be distinguished from smokers with no pulmonary tumors based on EBC cytokine signals only.
呼出气冷凝物（EBC）分析是一种有前途的气道病理学研究方法。在这项研究中，我们比较了患有鳞状细胞肺癌的患者和健康吸烟者的 EBC 细胞因子模式。收集了 8 名正在接受任何抗癌治疗的吸烟肺癌患者和 8 名没有任何临床或放射学肺部肿瘤证据的吸烟者的呼吸冷凝物，用于同时测试 120 种细胞因子的抗体微阵列分析。阵列上的 98 种细胞因子在两组中都给出了可检测的信号。细胞因子水平在样本之间相似，与具有相似吸烟状况、肺功能和气道炎症的健康吸烟者相比，癌症患者的细胞因子没有明显增加或减少。这项初步研究的结果表明，仅基于 EBC 细胞因子信号，无法将患有鳞状细胞肺癌的患者与没有肺部肿瘤的吸烟者区分开来。
