经路线转换的全合成导致产生有前途的细胞迁移抑制剂以治疗肿瘤转移：关于迁移他汀核心醚类似物的体内和机制研究。
Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.
机构信息
Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.
出版信息
J Am Chem Soc. 2010 Mar 10;132(9):3224-8. doi: 10.1021/ja9101503.
Abstract
A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells.
摘要
一种与天然产物米格列醇（migrastatin）显著简化的类似物，称为米格列醇醚（ME），已被制备并进行了评估。体内和体外研究均表明，ME 对乳腺癌细胞的迁移具有浓度依赖性抑制作用。
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