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1
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2
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3
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4
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ACS Chem Biol. 2007 Mar 20;2(3):159-62. doi: 10.1021/cb7000395.
5
Small molecule natural products in the discovery of therapeutic agents: the synthesis connection.
J Org Chem. 2006 Oct 27;71(22):8329-51. doi: 10.1021/jo0610053.
6
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Ann Oncol. 2006 May;17(5):735-49. doi: 10.1093/annonc/mdj100. Epub 2005 Dec 19.
7
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8
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9
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10
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