Grissinger Matthew, Gaunt Michael J
Institute for Safe Medication Practices.
Consult Pharm. 2009 Dec;24(12):864-72. doi: 10.4140/tcp.n.2009.864.
Fentanyl transdermal system is indicated for the management of persistent, moderate-to-severe chronic pain that requires continuous opioid administration for an extended period of time and cannot be managed by other means such as nonsteroidal analgesics, opioid combination products, or immediate-release opioids. The Institute for Safe Medication Practices and other patient safety advocates have long been concerned that transdermal fentanyl is often prescribed, dispensed, and administered without proper consideration of patient selection criteria, starting-dose recommendations, contraindications, dose adjustment recommendations, and safe administration procedures. This article will highlight errors that may arise during the use of fentanyl patches and provide risk-reduction recommendations for consultant pharmacists to address the potential for error and patient harm.
芬太尼透皮贴剂适用于治疗持续的、中度至重度慢性疼痛,这种疼痛需要长期持续使用阿片类药物,且无法通过其他方式(如非甾体类镇痛药、阿片类复方制剂或即释型阿片类药物)进行控制。长期以来,安全用药实践研究所及其他患者安全倡导者一直担心,在开具、调配和使用透皮芬太尼时,往往没有适当考虑患者选择标准、起始剂量建议、禁忌证、剂量调整建议及安全给药程序。本文将重点介绍使用芬太尼贴剂时可能出现的错误,并为临床药师提供降低风险的建议,以应对潜在的用药错误和患者伤害。