University of L'Aquila, Health Sciences, San Salvatore Street, Palace 6A, Coppito, L'Aquila, Italy.
Disabil Rehabil. 2010;32(14):1204-8. doi: 10.3109/09638280903511594.
To compare erectile function (EF) recovery of patients treated by early penile rehabilitation therapy (PRT) with sildenafil and with control group.
Forty men treated by bilateral nerve sparing radical prostatectomy (NSRP) and with a normal pre-operative EF were enrolled. Fourteen days after surgery, they were randomised to a flexible-dose sildenafil group and to a control group. The International Index of Erectile Function (IIEF) questionnaire was completed before surgery and at 3, 6, 12 and 24 weeks after NSRP.
In the group treated, the mean IIEF score before surgery was 26.2 and 14.1, 16.2, 22.5 and 25.2 at 3, 6, 12 and 24 weeks after NSRP, respectively. In the control group, the respective scores were 26.5 and 12.4, 15.8, 15.3 and 17.4. There was a significant difference in IIEF mean score (25+/-6 vs. 17+/-9, p<0.05) and in the potency rate (87% vs. 56%) between the groups at 24 weeks after NSRP. The percentage of patients who were capable of having medication-unassisted intercourse was 54% vs. 21%; 34% vs. 18% of patients had a normal EF with 72% vs. 32% of responders to sildenafil.
PRT with PDE-5 inhibitors should be offered early after RP to allow the recovery of EF.
比较早期阴茎康复治疗（PRT）联合西地那非与对照组治疗后患者勃起功能（EF）的恢复情况。
纳入 40 名接受双侧保留神经根治性前列腺切除术（NSRP）且术前 EF 正常的男性患者。术后 14 天，将他们随机分为灵活剂量西地那非组和对照组。在 NSRP 术前和术后 3、6、12 和 24 周时，使用国际勃起功能指数（IIEF）问卷进行评估。
在治疗组中，手术前的平均 IIEF 评分为 26.2，分别在术后 3、6、12 和 24 周时为 14.1、16.2、22.5 和 25.2。在对照组中，相应的评分分别为 26.5 和 12.4、15.8、15.3 和 17.4。在 NSRP 术后 24 周时，两组的 IIEF 平均评分（25+/-6 对 17+/-9，p<0.05）和勃起功能恢复率（87%对 56%）有显著差异。在 NSRP 术后 24 周时，能够进行药物辅助性交的患者比例分别为 54%对 21%；EF 正常的患者比例分别为 34%对 18%；对西地那非有反应的患者比例分别为 72%对 32%。
PRT 联合 PDE-5 抑制剂应在 RP 后早期应用，以恢复 EF。
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