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根治性前列腺切除术后阴茎康复的困惑。

Perplexity of penile rehabilitation following radical prostatectomy.

作者信息

Clavell-Hernandez Jonathan, Ermeç Bahadır, Kadıoğlu Ateş, Wang Run

机构信息

St Joseph Medical Center, Houston, Texas, USA.

Department of Urology İstinye State Hospital, İstanbul, Turkey.

出版信息

Turk J Urol. 2019 Jan 22;45(2):77-82. doi: 10.5152/tud.2019.18488. Print 2019 Mar.

DOI:10.5152/tud.2019.18488
PMID:30875285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6368034/
Abstract

Radical prostatectomy has significantly improved prostate cancer survival rates but continues to have a negative impact on the patient's erectile function (EF). In attempts to improve erectile dysfunction (ED), clinicians have incorporated different treatment modalities to restore EF. Penile rehabilitation consists of understanding the mechanisms that affect post-prostatectomy EF and utilizing pharmacologic agents, devices, and interventions to promote the male sexual function. This article aims to summarize the available scientific research involving penile rehabilitation. Even though the current literature lacks to prove its irrefutable effectiveness, penile rehabilitation has a positive impact at the molecular and cellular levels, and it is widely adopted in clinic practices.

摘要

根治性前列腺切除术显著提高了前列腺癌的生存率,但对患者的勃起功能(EF)仍有负面影响。为了改善勃起功能障碍(ED),临床医生采用了不同的治疗方式来恢复勃起功能。阴茎康复包括了解影响前列腺切除术后勃起功能的机制,并利用药物、器械和干预措施来促进男性性功能。本文旨在总结有关阴茎康复的现有科学研究。尽管目前的文献缺乏确凿证据证明其绝对有效性,但阴茎康复在分子和细胞水平上有积极影响,且在临床实践中被广泛采用。

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本文引用的文献

1
Penile Rehabilitation Therapy Following Radical Prostatectomy: A Meta-Analysis.根治性前列腺切除术后的阴茎康复治疗:一项荟萃分析。
J Sex Med. 2017 Dec;14(12):1496-1503. doi: 10.1016/j.jsxm.2017.09.020. Epub 2017 Nov 6.
2
The controversy surrounding penile rehabilitation after radical prostatectomy.根治性前列腺切除术后阴茎康复的相关争议。
Transl Androl Urol. 2017 Feb;6(1):2-11. doi: 10.21037/tau.2016.08.14.
3
Effects of Tadalafil Once-Daily or On-Demand vs Placebo on Return to Baseline Erectile Function After Bilateral Nerve-Sparing Radical Prostatectomy--Results from a Randomized Controlled Trial (REACTT).他达拉非每日一次或按需服用与安慰剂对双侧保留神经的根治性前列腺切除术后勃起功能恢复至基线水平的影响——一项随机对照试验(REACTT)的结果
J Sex Med. 2016 Apr;13(4):679-83. doi: 10.1016/j.jsxm.2016.01.022. Epub 2016 Mar 25.
4
Prevention and management of post prostatectomy erectile dysfunction.前列腺切除术后勃起功能障碍的预防与管理
Transl Androl Urol. 2015 Aug;4(4):421-37. doi: 10.3978/j.issn.2223-4683.2013.09.10.
5
A prospective, randomized, placebo-controlled trial of on-Demand vs. nightly sildenafil citrate as assessed by Rigiscan and the international index of erectile function.一项通过阴茎硬度扫描仪(Rigiscan)和国际勃起功能指数评估按需服用与每晚服用枸橼酸西地那非的前瞻性、随机、安慰剂对照试验。
Andrology. 2016 Jan;4(1):27-32. doi: 10.1111/andr.12118. Epub 2015 Dec 10.
6
Urinary Incontinence and Erectile Dysfunction After Robotic Versus Open Radical Prostatectomy: A Prospective, Controlled, Nonrandomised Trial.机器人辅助与开放性根治性前列腺切除术治疗后尿失禁和勃起功能障碍:一项前瞻性、对照、非随机试验。
Eur Urol. 2015 Aug;68(2):216-25. doi: 10.1016/j.eururo.2015.02.029. Epub 2015 Mar 12.
7
Penile rehabilitation: the evolutionary concept in the management of erectile dysfunction.阴茎康复:勃起功能障碍管理中的进化概念。
Curr Urol Rep. 2014 Apr;15(4):393. doi: 10.1007/s11934-014-0393-6.
8
Effects of tadalafil treatment on erectile function recovery following bilateral nerve-sparing radical prostatectomy: a randomised placebo-controlled study (REACTT).他达拉非治疗双侧神经保留根治性前列腺切除术后勃起功能恢复的效果:一项随机安慰剂对照研究(REACTT)。
Eur Urol. 2014 Mar;65(3):587-96. doi: 10.1016/j.eururo.2013.09.051. Epub 2013 Oct 13.
9
Nightly vs on-demand sildenafil for penile rehabilitation after minimally invasive nerve-sparing radical prostatectomy: results of a randomized double-blind trial with placebo.微创神经保留根治性前列腺切除术后按需与每晚服用西地那非进行阴茎康复治疗的随机双盲安慰剂对照试验结果。
BJU Int. 2013 Oct;112(6):844-51. doi: 10.1111/bju.12253. Epub 2013 Aug 13.
10
Penile rehabilitation with a vacuum erectile device in an animal model is related to an antihypoxic mechanism: blood gas evidence.在动物模型中,使用真空勃起装置进行阴茎康复与抗缺氧机制有关:血气证据。
Asian J Androl. 2013 May;15(3):387-90. doi: 10.1038/aja.2013.18. Epub 2013 Apr 8.