Arteriosklerose-Praeventions-Institut, Munich-Nuremberg, Germany.
Metab Syndr Relat Disord. 2010 Apr;8(2):189-92. doi: 10.1089/met.2009.0054.
Globalization of the western lifestyle may contribute to worldwide increases of adiposity and type 2 diabetes. In combination with genetic influences, this results in different prevalence rates among different ethnicities, particularly at younger ages. Since 2007, the unified pediatric definition of the metabolic syndrome by the International Diabetes Federation (IDF) has allowed a global comparison of the prevalence. Therefore, we compared the prevalence of the metabolic syndrome and its components in two large representative samples of adolescents in Germany and Iran.
We used data from 3,647 German adolescents aged 10-15 years old participating in the German PEP Family Heart Study and 2,728 Iranians in the same age range participating in the CASPIAN Study.
The metabolic syndrome was four times more prevalent in Iranian (2.1%) than in German (0.5%) adolescents. The prevalence of three components of the metabolic syndrome was significantly (P < 0.0001) higher in Iranian than in German adolescents-the prerequisite abdominal obesity (11.1% vs. 11.4% vs 1.9%), low-serum high-density lipoprotein cholesterol (HDL-C) (41.9% vs. 7.2%) and hypertriglyceridemia (7.2% vs. 11.4%).
The prevalence of the metabolic syndrome according to pediatric IDF criteria and its three main components differed considerably in two large ethnicities. The clinical impacts of these findings should be confirmed in future longitudinal studies.
西方生活方式的全球化可能导致肥胖症和 2 型糖尿病在全球范围内的发病率上升。这种情况加上遗传因素的影响，导致不同种族之间的发病率存在差异，尤其是在年轻人中。自 2007 年以来，国际糖尿病联合会（IDF）对代谢综合征的统一儿科定义使得可以进行全球范围内的患病率比较。因此，我们比较了德国和伊朗两个大型代表性青少年样本中代谢综合征及其成分的患病率。
我们使用了德国 PEP 家庭心脏研究中年龄在 10-15 岁的 3647 名德国青少年和同年龄段的伊朗 CASPIAN 研究中的 2728 名伊朗青少年的数据。
伊朗青少年（2.1%）中代谢综合征的患病率是德国青少年（0.5%）的四倍。伊朗青少年代谢综合征三个成分的患病率明显高于德国青少年-必要的腹部肥胖（11.1%比 11.4%比 1.9%），血清高密度脂蛋白胆固醇（HDL-C）低（41.9%比 7.2%）和高三酰甘油血症（7.2%比 11.4%）。
根据儿科 IDF 标准和其三个主要成分，代谢综合征在两个主要种族之间的患病率差异很大。这些发现的临床影响应在未来的纵向研究中得到证实。
