García-Merino Isabel, de Las Cuevas Natividad, Jiménez José Luis, García Almudena, Gallego Jorge, Gómez Coral, García Dolores, Muñoz-Fernández Ma Angeles
Laboratorio de Inmunobiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid , Spain.
AIDS Res Hum Retroviruses. 2010 Feb;26(2):241-4. doi: 10.1089/aid.2009.0122.
The vulnerability of children has long raised ethical concerns resulting in the lack of inclusion of children in research studies. This has impeded the development of relevant medical therapies specific for children. In response to these circumstances, international policies have begun to recognize the need to carry out research focused on children. Translational HIV infection research is highly dependent on many factors including the availability, quality, and traceability of samples and their associated data under a strict system of quality management. The primary objective of the Pediatric HIV BioBank is to contribute to the furthering of scientific knowledge about vertical HIV infection. To achieve this aim, the BioBank processes, stores, and provides distinct samples from HIV/AIDS children to research projects free of charge. Strict compliance to ethical norms is always guaranteed. At present the Pediatric HIV BioBank has 429 vials containing different sample types from 243 vertically HIV-infected children. The Pediatric HIV BioBank represents a novel approach to HIV research that might be of general interest not only for basic and clinical research teams working with HIV, but also for those groups trying to establish large networks focused on researching specific clinical problems. It also represents a model to stimulate cooperative research on specific clinical problems. The main objective of this article is to show the structure and function of the Pediatric HIV BioBank that allow it to efficiently provide samples to different research projects in Spain and in other countries.
长期以来，儿童的脆弱性引发了伦理问题，导致儿童被排除在研究之外。这阻碍了针对儿童的相关医学疗法的发展。针对这些情况，国际政策已开始认识到开展针对儿童的研究的必要性。转化性艾滋病毒感染研究高度依赖许多因素，包括在严格的质量管理体系下样本及其相关数据的可获得性、质量和可追溯性。儿科艾滋病毒生物样本库的主要目标是推动有关垂直艾滋病毒感染的科学知识的进一步发展。为实现这一目标，生物样本库处理、存储并免费向研究项目提供来自艾滋病毒/艾滋病儿童的不同样本。始终确保严格遵守伦理规范。目前，儿科艾滋病毒生物样本库有429个小瓶，包含来自243名垂直感染艾滋病毒儿童的不同样本类型。儿科艾滋病毒生物样本库代表了一种新的艾滋病毒研究方法，不仅可能引起从事艾滋病毒研究的基础和临床研究团队的普遍兴趣，也可能引起那些试图建立专注于研究特定临床问题的大型网络的群体的兴趣。它还代表了一种促进针对特定临床问题开展合作研究的模式。本文的主要目的是展示儿科艾滋病毒生物样本库的结构和功能，使其能够有效地向西班牙和其他国家的不同研究项目提供样本。
