Department of Biology, Graduate School of Science, Osaka University, Osaka, Japan.
Evol Dev. 2010 Jan-Feb;12(1):25-33. doi: 10.1111/j.1525-142X.2009.00388.x.
The highly specialized cephalopod cardiovascular system has long been considered a valuable model for understanding the evolution of circulatory systems. Despite the number of studies devoted to this topic, the developmental regulatory mechanisms remain largely unexplored. Here, we focus on the vascular endothelial growth factor receptor (VEGFR). This factor is known to mediate levels of endothelial growth factor that is involved in hematopoiesis and vasculogenesis including multichambered heart development in vertebrates. We found a squid VEGFR ortholog that is expressed in the developing blood vessels, notably in the sheet-like endothelial cells of the systemic and branchial hearts. The highly restricted localization of VEGFR in the vascular endothelial cells and its shared expression pattern in the developing hearts of cephalopods and vertebrates suggest a shared molecular signature of closed circulatory systems that has been independently elaborated during evolution.
高度专业化的头足类心血管系统一直被认为是理解循环系统进化的有价值的模型。尽管有许多研究致力于这个主题，但发育调节机制在很大程度上仍未得到探索。在这里，我们专注于血管内皮生长因子受体 (VEGFR)。该因子已知介导内皮生长因子的水平，该因子参与造血和血管生成，包括脊椎动物的多腔心脏发育。我们发现了一种鱿鱼 VEGFR 同源物，它在正在发育的血管中表达，特别是在系统性和鳃心脏的片状内皮细胞中表达。VEGFR 在血管内皮细胞中的高度受限定位及其在头足类动物和脊椎动物发育心脏中的共同表达模式表明，封闭循环系统具有共同的分子特征，这些特征在进化过程中是独立形成的。
