Crit Care. 2010;14(1):113. doi: 10.1186/cc8225. Epub 2010 Feb 8.
The importance of adrenal function to survival in critically ill patients has been established; however, identifying the best method to diagnose adrenal insufficiency has been problematic. Multiple methods of determining adrenal function have been developed, each with its advantages and disadvantages. Serum-free cortisol levels are probably the most accurate, although obtaining this result is technically demanding. Cohen and colleagues investigated the feasibility of measuring tissue cortisol levels in burn patients and whether tissue cortisol levels could be used as a surrogate for plasma-free cortisol levels.
肾上腺功能对危重症患者的生存至关重要；然而，确定诊断肾上腺功能不全的最佳方法一直是个问题。已经开发出多种确定肾上腺功能的方法，每种方法都有其优点和缺点。血清游离皮质醇水平可能是最准确的，尽管获得该结果在技术上具有挑战性。Cohen 及其同事研究了测量烧伤患者组织皮质醇水平的可行性，以及组织皮质醇水平是否可以作为血浆游离皮质醇水平的替代物。
