Discipline of Physiotherapy, Trinity Centre for Health Sciences, St James's Hospital, Dublin 8, Ireland.
BMC Cancer. 2010 Feb 15;10:42. doi: 10.1186/1471-2407-10-42.
Many cancer survivors suffer a range of physical and psychological symptoms which may persist for months or years after cessation of treatment. Despite the known benefits of exercise and its potential to address many of the adverse effects of treatment, the role of exercise as well as optimum duration, frequency, and intensity in this population has yet to be fully elucidated. Many cancer rehabilitation programmes presented in the literature are very long and have tight eligibility criteria which make them non-applicable to the majority of cancer survivors. This paper presents the protocol of a novel 8-week intervention which aims to increase fitness, and address other physical symptoms in a heterogeneous cancer survivor population.
METHODS/DESIGN: The aim is to recruit 64 cancer survivors 2-6 months after completion of chemotherapy, usually adjuvant, with curative intent. Subjects will be recruited through oncology clinics in a single institution and randomised to usual care or an exercise intervention. The exercise intervention consists of two specifically tailored supervised moderate intensity aerobic exercise sessions weekly over 8-weeks. All participants will be assessed at baseline (0 weeks), at the end of the intervention (8 weeks), and at 3-month follow-up. The primary outcome measure is fitness, and secondary patient-related outcome measures include fatigue, quality of life, and morphological outcomes. A further secondary outcome is process evaluation including adherence to and compliance with the exercise program.
This study will provide valuable information about the physical outcomes of this 8-week supervised aerobic programme. Additionally, process information and economic evaluation will inform the feasibility of implementing this program in a heterogeneous population post cessation of chemotherapy.
许多癌症幸存者在治疗停止后数月甚至数年内仍会遭受一系列身体和心理症状的困扰。尽管运动的益处已被广泛认可，且其具有改善治疗副作用的潜力，但在这一人群中，运动的作用以及最佳持续时间、频率和强度尚未得到充分阐明。文献中提出的许多癌症康复方案非常长，且有严格的资格标准，使得它们不适用于大多数癌症幸存者。本文介绍了一项新的 8 周干预方案的方案，旨在提高适应性，并解决异质癌症幸存者群体中的其他身体症状。
方法/设计：目标是招募 64 名癌症幸存者，他们在完成化疗后 2-6 个月，通常是辅助性的，具有治愈目的。参与者将通过单一机构的肿瘤诊所招募，并随机分配至常规护理或运动干预组。运动干预包括每周两次、为期 8 周的两次专门定制的监督性中等强度有氧运动课程。所有参与者将在基线（0 周）、干预结束时（8 周）和 3 个月随访时进行评估。主要结局测量是适应性，次要患者相关结局测量包括疲劳、生活质量和形态学结局。进一步的次要结局是过程评估，包括对运动方案的依从性和遵守情况。
这项研究将提供有关该 8 周监督性有氧运动方案的身体结果的宝贵信息。此外，过程信息和经济评估将为在化疗停止后在异质人群中实施该方案的可行性提供信息。
