School of Medicine, Trinity Centre for Health Science, St. James's Hospital, St. James's Street, Dublin 8, Ireland,
J Cancer Surviv. 2013 Dec;7(4):551-62. doi: 10.1007/s11764-013-0294-6. Epub 2013 Jun 9.
This study aims to evaluate the feasibility and efficacy of an 8-week supervised exercise program in de-conditioned cancer survivors within 2-6 months of chemotherapy completion.
Participants were randomly assigned to an 8-week, twice-weekly, supervised aerobic exercise training regime (n = 23) or a usual care group (n = 20). Feasibility was assessed by recruitment rate, program adherence and participant feedback. The primary outcome was aerobic fitness assessed by the Modified Bruce fitness test at baseline (0 weeks), post-intervention (8 weeks) and at 3-month follow-up. Secondary outcomes included physical activity, waist circumference, fatigue and quality of life.
The recruitment rate was 81 % and adherence to the supervised exercise was 78.3 %. Meaningful differences in aerobic fitness between the exercise and usual care groups at both the 8-week [mean 3.0 mL kg(-1) min(-1) (95 % CI -1.1-7.0)] and 3-month follow-up [2.1 mL kg(-1) min(-1) (-2.3-6.6)] were found, although these differences did not achieve statistical significance (p values >0.14). Self-reported physical activity increased in the exercise group (EG) compared to the usual care group at both 8-week (p = 0.01) and 3-month follow-up (p = 0.03) and significant differences in favour of the EG were found for physical well-being at both the 8-week (p = 0.03) and 3-month follow-up (p = 0.04). Improvements in fatigue (p = 0.01), total quality of life plus fatigue (p = 0.04), and a composite physical functioning score (p = 0.01) at the 3-month follow-up were also found.
The PEACH trial suggests that 8 weeks of supervised aerobic exercise training was feasible and may improve aerobic fitness, fatigue and quality of life in de-conditioned cancer survivors during the early survivorship phase.
Exercise interventions commenced in the early survivorship phase appear safe, feasible and may lead to improvements in QOL and fatigue.
本研究旨在评估在化疗结束后 2-6 个月内，对处于适应不良状态的癌症幸存者进行 8 周监督下的运动方案的可行性和疗效。
参与者被随机分配到 8 周、每周两次的监督有氧运动训练组（n=23）或常规护理组（n=20）。通过招募率、方案依从性和参与者反馈来评估可行性。主要结局指标是通过改良布鲁斯健身测试在基线（0 周）、干预后（8 周）和 3 个月随访时评估的有氧健身。次要结局指标包括身体活动、腰围、疲劳和生活质量。
招募率为 81%，监督运动的依从率为 78.3%。在 8 周和 3 个月随访时，运动组和常规护理组之间在有氧健身方面均存在有意义的差异[运动组平均 3.0 毫升公斤(-1)分钟(-1)（95%置信区间-1.1 至 7.0）]，尽管这些差异没有达到统计学意义（p 值>0.14）。与常规护理组相比，运动组在 8 周和 3 个月随访时的自我报告身体活动均增加（p=0.01 和 p=0.03），并且在 8 周和 3 个月随访时，运动组在身体幸福感方面均具有显著优势（p=0.03 和 p=0.04）。在 3 个月随访时还发现疲劳（p=0.01）、总生活质量加疲劳（p=0.04）和综合身体功能评分（p=0.01）的改善。
PEACH 试验表明，8 周的监督有氧运动训练是可行的，可能会改善适应不良的癌症幸存者在早期生存阶段的有氧健身、疲劳和生活质量。
在早期生存阶段开始的运动干预似乎是安全可行的，并且可能会改善生活质量和疲劳感。
