Discipline of Physiotherapy, School of Medicine, Trinity College Dublin, Dublin, Ireland.
Support Care Cancer. 2013 Jul;21(7):1983-92. doi: 10.1007/s00520-013-1743-5. Epub 2013 Feb 22.
Physical activity is associated with a reduced risk of breast cancer development and recurrence. There are several hypothesised mechanisms for this including positive effects on metabolic and inflammatory biomarkers and favourable changes in anthropometric variables. This pilot study examined the effect of an 8-week aerobic exercise intervention on several of these outcomes, including body composition, the metabolic syndrome, C-reactive protein (CRP) and physical activity, in breast cancer survivors 2-6 months post-chemotherapy.
Assessments were completed at baseline, at 8-weeks and 3-months post-intervention. Measures taken following a 12-h fast included body composition (bioimpedance analysis), metabolic syndrome (waist circumference, blood pressure, high-density lipoprotein cholesterol, triglycerides and fasting glucose), insulin resistance (homeostatic model assessment), CRP and physical activity (accelerometry and questionnaire). Participants were randomized to either an 8-week moderate-intensity aerobic exercise group or a usual-care control group. Analysis was completed using repeated-measures analysis of variance (ANOVA) (p = 0.05).
Twenty-six breast cancer survivors participated (mean (standard deviation) age 48.1 (8.8) years, exercise group; n = 16, control group; n = 10). At baseline, 13 participants were overweight, 6 were obese and 19 centrally obese. Intention-to-treat analysis revealed no significant differences between the exercise and control groups in any of the outcomes measures; however, analysis of those who adhered to >90 % of the supervised exercise class showed a significant decrease in waist circumference (p = 0.05) and a significant increase in subjectively reported "total weekly" (p = 0.005) activity.
While this 8-week aerobic exercise pilot intervention did not elicit significant improvements in biomarkers of breast cancer risk, there was some suggestion of improvements in waist circumference and subjectively measured physical activity in participants with >90 % adherence to the programme. A trial of longer duration and greater subject numbers is warranted.
身体活动与降低乳腺癌发展和复发的风险有关。其可能的机制包括对代谢和炎症生物标志物的积极影响，以及人体测量学变量的有利变化。本初步研究检测了 8 周有氧运动干预对这些结果中的几个结果的影响，包括乳腺癌幸存者化疗后 2-6 个月的身体成分、代谢综合征、C 反应蛋白（CRP）和身体活动。
在基线、8 周和干预后 3 个月进行评估。空腹 12 小时后进行的测量包括身体成分（生物电阻抗分析）、代谢综合征（腰围、血压、高密度脂蛋白胆固醇、甘油三酯和空腹血糖）、胰岛素抵抗（稳态模型评估）、CRP 和身体活动（加速度计和问卷）。参与者被随机分配到 8 周中等强度有氧运动组或常规护理对照组。使用重复测量方差分析（ANOVA）（p = 0.05）进行分析。
共有 26 名乳腺癌幸存者参与（平均（标准差）年龄 48.1（8.8）岁，运动组 n = 16，对照组 n = 10）。基线时，13 名参与者超重，6 名肥胖，19 名中心性肥胖。意向治疗分析显示，在任何结果测量中，运动组和对照组之间均无显著差异；然而，对遵守 >90%监督锻炼课的参与者进行分析显示，腰围显著减小（p = 0.05），主观报告的“总周”活动显著增加（p = 0.005）。
虽然这项 8 周有氧运动初步干预没有引起乳腺癌风险生物标志物的显著改善，但在遵守方案 >90%的参与者中，腰围和主观测量的身体活动有一定改善的迹象。需要进行更长时间和更大规模的试验。
