Department of Hygiene and Epidemiology, Faculty of Health Sciences of Collegium Medicum, Bydgoszcz, Poland.
Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):126-7. doi: 10.1186/2047-783x-14-s4-126.
Our previous study demonstrated that selective carotid baroreceptors activation decreases airway resistance. The aim of the present study was to evaluate the effect of carotid baroreceptor inactivation on the reflex change of respiratory resistance. Twenty healthy men aged between 20 and 25 were included in the study. Selective inactivation of carotid baroreceptors was induced by generating a positive pressure of 40 mmHg for 5 s in two capsules placed bilaterally on the neck over the bifurcation of the carotid arteries. The oscillatory method (Siregnost FD5, Siemens) was used to measure continuously respiratory resistance. Inactivation of carotid baroreceptors produced a short increase in respiratory resistance by 0.39 +/- 0.01(SE) mbar/l/s, i.e., 21.7% above the resting level. We conclude that in humans, carotid baroreceptors might have a background contribution to bronchodilator tone. This observation seems to be important for clinical situations of impairment of baroreflex function.
我们之前的研究表明，选择性颈动脉压力感受器激活可降低气道阻力。本研究旨在评估颈动脉压力感受器失活对呼吸阻力反射变化的影响。20 名年龄在 20 至 25 岁之间的健康男性参与了这项研究。通过在颈动脉分叉处颈部两侧的两个胶囊上产生 40mmHg 的正压 5s 来选择性地失活颈动脉压力感受器。采用振荡法（Siregnost FD5，西门子）连续测量呼吸阻力。颈动脉压力感受器失活使呼吸阻力短暂增加 0.39 +/- 0.01(SE) mbar/l/s，即比静息水平高 21.7%。我们的结论是，在人类中，颈动脉压力感受器可能对支气管扩张剂张力有背景贡献。这一观察结果对于压力反射功能受损的临床情况似乎很重要。
