Spira J, Povey S, Wiener F, Klein G, Andersson-Anvret M
Int J Cancer. 1977 Dec 15;20(6):849-53. doi: 10.1002/ijc.2910200605.
Four independently fused hybrid clones derived from a cross between the mouse mammary carcinoma TA3Ha and the human Burkitt lymphoma line Daudi were tested for the EBV-determined nuclear antigen (EBNA), EBV-DNA and the presence of human chromosomes, in the course of serial propagation in vitro. EBNA and EBV-DNA were lost in parallel with the loss of human chromosomes. It seems that the persistence of EB-viral genetic information does not require the presence of a specific human chromosome(s) in this particular hybrid combination.
对从小鼠乳腺癌TA3Ha与人伯基特淋巴瘤细胞系Daudi杂交得到的四个独立融合的杂交克隆，在体外连续传代过程中进行了EB病毒核抗原（EBNA）、EB病毒DNA以及人类染色体存在情况的检测。EBNA和EB病毒DNA随着人类染色体的丢失而平行丢失。在这种特定的杂交组合中，EB病毒遗传信息的持续存在似乎并不需要特定人类染色体的存在。
