一次控制一种底物的干细胞命运。 - Suppr

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超能文献

Controlling stem cell fate one substrate at a time.

作者信息

Garrison Brian S, Rossi Derrick J

出版信息

Nat Immunol. 2010 Mar;11(3):193-4. doi: 10.1038/ni0310-193.

DOI:10.1038/ni0310-193

PMID:20157300

Abstract

摘要

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Controlling stem cell fate one substrate at a time.一次控制一种底物的干细胞命运。

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Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex.由单个泛素连接酶-底物复合物调节造血干细胞分化。

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c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation.c-Myc控制造血干细胞自我更新与分化之间的平衡。

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[Cell cycle regulation by F-box protein Fbxw7].[F-box蛋白Fbxw7对细胞周期的调控]

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c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development.在成体造血干细胞和巨核细胞发育的调控中，c-Myc是RNA结合基序蛋白15的一个靶点。

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Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity.造血干细胞的功能和存活依赖于c-Myc和N-Myc的活性。

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The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells.E3 连接酶 Itch 是造血干细胞自我平衡和功能的负调控因子。

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The ARID family transcription factor bright is required for both hematopoietic stem cell and B lineage development.ARID 家族转录因子 bright 对于造血干细胞和 B 细胞谱系发育都是必需的。

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本文引用的文献

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex.由单个泛素连接酶-底物复合物调节造血干细胞分化。

Nat Immunol. 2010 Mar;11(3):207-15. doi: 10.1038/ni.1839. Epub 2010 Jan 17.

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.造血干细胞在稳态和修复过程中从休眠状态可逆地转变为自我更新状态。

Cell. 2008 Dec 12;135(6):1118-29. doi: 10.1016/j.cell.2008.10.048.

Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity.造血干细胞的功能和存活依赖于c-Myc和N-Myc的活性。

Cell Stem Cell. 2008 Dec 4;3(6):611-24. doi: 10.1016/j.stem.2008.09.005.

Fbxw7 in cell cycle exit and stem cell maintenance: insight from gene-targeted mice.Fbxw7在细胞周期退出和干细胞维持中的作用：来自基因敲除小鼠的见解

Cell Cycle. 2008 Nov 1;7(21):3307-13. doi: 10.4161/cc.7.21.6931. Epub 2008 Nov 5.

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7.E3泛素连接酶Fbw7对造血干细胞静止状态的调控

J Exp Med. 2008 Jun 9;205(6):1395-408. doi: 10.1084/jem.20080277. Epub 2008 May 12.

The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.E3泛素连接酶c-Cbl限制造血干细胞的发育和功能。

Genes Dev. 2008 Apr 15;22(8):992-7. doi: 10.1101/gad.1651408.

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.Fbxw7作为防止造血干细胞过早丢失和T细胞急性淋巴细胞白血病发生的关键安全保障机制。

Genes Dev. 2008 Apr 15;22(8):986-91. doi: 10.1101/gad.1621808. Epub 2008 Mar 26.

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation.FBW7泛素连接酶：细胞分裂、生长与分化交汇点上的一种肿瘤抑制因子

Nat Rev Cancer. 2008 Feb;8(2):83-93. doi: 10.1038/nrc2290.

c-Myc is essential for hematopoietic stem cell differentiation and regulates Lin(-)Sca-1(+)c-Kit(-) cell generation through p21.c-Myc对造血干细胞分化至关重要，并通过p21调节Lin(-)Sca-1(+)c-Kit(-)细胞的生成。

Exp Hematol. 2007 Sep;35(9):1333-43. doi: 10.1016/j.exphem.2007.05.015. Epub 2007 Jul 16.

Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect.造血干细胞在出生前持续增殖，并表现出可逆的阶段特异性植入缺陷。

J Clin Invest. 2006 Oct;116(10):2808-16. doi: 10.1172/JCI28310.

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