Sears Rosalie C
Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland 97239, USA.
Cell Cycle. 2004 Sep;3(9):1133-7. Epub 2004 Sep 5.
The c-Myc transcription factor is a potent regulator of cellular proliferation and cell fate decision. Precise regulation of c-Myc protein levels is essential to maintain normal cell function. In order to maintain proper levels of c-Myc, its protein stability is tightly controlled. c-Myc is degraded through the ubiquitin-proteasome pathway. This perspective discusses a sophisticated and complex signaling pathway that controls the life cycle of c-Myc from protein synthesis to ubiquitin-mediated degradation. The pathway involves Ras-activated kinases, the Pin1 prolyl isomerase, the PP2A phosphatase and a series of c-Myc phosphorylation and dephosphorylation events that control its stability.
c-Myc转录因子是细胞增殖和细胞命运决定的有效调节因子。精确调控c-Myc蛋白水平对于维持正常细胞功能至关重要。为了维持c-Myc的适当水平，其蛋白稳定性受到严格控制。c-Myc通过泛素-蛋白酶体途径降解。本文探讨了一条复杂精密的信号通路，该通路控制着c-Myc从蛋白质合成到泛素介导降解的生命周期。该通路涉及Ras激活的激酶、Pin1脯氨酰异构酶、PP2A磷酸酶以及一系列控制其稳定性的c-Myc磷酸化和去磷酸化事件。
