Cho Hee Yoon, Lee Dong Hoon, Chung Song Ee, Kang Se Woong
Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Korea.
Korean J Ophthalmol. 2010 Feb;24(1):16-22. doi: 10.3341/kjo.2010.24.1.16. Epub 2010 Feb 5.
To assess the diagnostic efficacy of macular and peripapillary retinal thickness measurements for the staging of diabetic retinopathy (DR) and the prediction of disease progression.
In this prospective study, 149 diabetic patients (149 eyes) and 50 non-diabetic control subjects were included. Baseline optical coherence tomography was employed to measure retinal thickness in the macula (horizontal, vertical, and central) and the peripapillary zone (superior, inferior, nasal, and concentric to the optic disc). Seven baseline parameters were correlated with the DR stages identified by fluorescein angiography. Baseline retinal thickness was compared between groups of patients requiring panretinal photocoagulation (PRP) within 6 months (PRP group) and patients not requiring PRP (No-PRP group).
Macular and peripapillary retinal thicknesses in diabetic subjects were significantly greater than that in normal controls (p<0.05). All retinal thickness parameters, and particularly peripapillary circular scans, tended to increase with increasing DR severity (p<0.05). The baseline thicknesses of the peripapillary circular scans were greater in the PRP group than in the no-PRP group (p<0.05).
Peripapillary retinal thickness may prove to be a useful criterion for DR severity and may also serve as an indicator of disease progression.
评估黄斑和视乳头周围视网膜厚度测量对糖尿病视网膜病变（DR）分期及疾病进展预测的诊断效能。
在这项前瞻性研究中，纳入了149例糖尿病患者（149只眼）和50例非糖尿病对照者。采用基线光学相干断层扫描测量黄斑区（水平、垂直和中心）及视乳头周围区域（上方、下方、鼻侧以及与视盘同心）的视网膜厚度。将七个基线参数与荧光素血管造影确定的DR分期进行相关性分析。比较了6个月内需要进行全视网膜光凝（PRP）的患者组（PRP组）和不需要进行PRP的患者组（非PRP组）的基线视网膜厚度。
糖尿病患者的黄斑和视乳头周围视网膜厚度显著大于正常对照组（p<0.05）。所有视网膜厚度参数，尤其是视乳头周围环形扫描，随着DR严重程度的增加而趋于增加（p<0.05）。PRP组视乳头周围环形扫描的基线厚度大于非PRP组（p<0.05）。
视乳头周围视网膜厚度可能是DR严重程度的一个有用标准，也可作为疾病进展的指标。
