Partners in death: a role for p73 and NF-kB in promoting apoptosis.
作者信息
Vousden Karen H
机构信息
The Beatson Institute for Cancer Research, Garscube Estate, Glasgow G611BD, UK.
出版信息
Aging (Albany NY). 2009 Mar 28;1(3):275-7. doi: 10.18632/aging.100033.
Abstract
摘要
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TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.TAp73基因敲除显示出基因组不稳定，并伴有不育和肿瘤抑制功能。
Genes Dev. 2008 Oct 1;22(19):2677-91. doi: 10.1101/gad.1695308. Epub 2008 Sep 19.
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Cytochrome c: functions beyond respiration.细胞色素c：呼吸作用之外的功能。
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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis.IAP拮抗剂靶向cIAP1以诱导肿瘤坏死因子α依赖性凋亡。
Cell. 2007 Nov 16;131(4):682-93. doi: 10.1016/j.cell.2007.10.037.
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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.IAP拮抗剂可诱导c-IAPs的自身泛素化、NF-κB激活以及TNFα依赖性凋亡。
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Good cop, bad cop: the different faces of NF-kappaB.红脸白脸：核因子κB的不同面孔
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Loss of nuclear factor-kappaB is tumor promoting but does not substitute for loss of p53.核因子-κB缺失具有促肿瘤作用，但不能替代p53缺失。
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Science. 2003 Nov 7;302(5647):1036-8. doi: 10.1126/science.1090072. Epub 2003 Sep 18.
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