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Partners in death: a role for p73 and NF-kB in promoting apoptosis.

作者信息

Vousden Karen H

机构信息

The Beatson Institute for Cancer Research, Garscube Estate, Glasgow G611BD, UK.

出版信息

Aging (Albany NY). 2009 Mar 28;1(3):275-7. doi: 10.18632/aging.100033.

Abstract
摘要

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Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-kappaB pathways.
Nat Rev Drug Discov. 2008 Dec;7(12):1031-40. doi: 10.1038/nrd2759.
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TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.
Genes Dev. 2008 Oct 1;22(19):2677-91. doi: 10.1101/gad.1695308. Epub 2008 Sep 19.
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Cytochrome c: functions beyond respiration.
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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.
Science. 2003 Nov 7;302(5647):1036-8. doi: 10.1126/science.1090072. Epub 2003 Sep 18.

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