Blagosklonny Mikhail V, Hall Michael N
Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Aging (Albany NY). 2009 Apr 20;1(4):357-62. doi: 10.18632/aging.100040.
It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.
人们通常认为生长和衰老之间存在某种联系，但这种联系的本质一直难以捉摸。在这里，我们将衰老过程视为由TOR驱动的生长的延续。TOR对于发育生长绝对至关重要，但发育完成后，它会导致衰老和与年龄相关的疾病。因此，营养感知和促进生长的TOR信号通路可能在从酵母到人类的整个生物界中提供生长与衰老之间的分子联系。
