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SNP'ing for longevity.

作者信息

Vijg Jan

机构信息

Albert Einstein College of Medicine, Bronx, NY 10461, USA.

出版信息

Aging (Albany NY). 2009 May 6;1(5):442-3. doi: 10.18632/aging.100048.

DOI:10.18632/aging.100048
PMID:20157528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2806028/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502f/2806028/405406f746df/aging-01-442-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502f/2806028/405406f746df/aging-01-442-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/502f/2806028/405406f746df/aging-01-442-g001.jpg

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本文引用的文献

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2
Human models of aging and longevity.衰老与长寿的人类模型。
Expert Opin Biol Ther. 2008 Sep;8(9):1393-405. doi: 10.1517/14712598.8.9.1393.
3
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation.
Cdkn1a基因缺失可改善端粒功能异常小鼠的干细胞功能和寿命，且不会加速癌症形成。
Nat Genet. 2007 Jan;39(1):99-105. doi: 10.1038/ng1937. Epub 2006 Dec 3.
4
Aging and p53: getting it straight. A commentary on a recent paper by Gentry and Venkatachalam.衰老与p53：厘清关系。对金特里和文卡塔查拉姆近期一篇论文的评论
Aging Cell. 2005 Dec;4(6):331-3. doi: 10.1111/j.1474-9726.2005.00179.x.
5
Lost in transcription: p21 repression, mechanisms, and consequences.转录中的迷失：p21基因的抑制、机制及后果
Cancer Res. 2005 May 15;65(10):3980-5. doi: 10.1158/0008-5472.CAN-04-3995.
6
Genetics of longevity and aging.长寿与衰老的遗传学
Annu Rev Med. 2005;56:193-212. doi: 10.1146/annurev.med.56.082103.104617.
7
p53 mutant mice that display early ageing-associated phenotypes.表现出与早衰相关表型的p53突变小鼠。
Nature. 2002 Jan 3;415(6867):45-53. doi: 10.1038/415045a.
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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.缺乏p21CIP1/WAF1的小鼠能正常发育，但在G1期关卡控制方面存在缺陷。
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