Yashin Anatoliy I, Wu Deqing, Arbeev Konstantin G, Ukraintseva Svetlana V
Center for Population Health and Aging, Duke University, Durham, NC 27708-0408, USA.
Aging (Albany NY). 2010 Sep;2(9):612-20. doi: 10.18632/aging.100191.
The results of genome-wide association studies of complex traits, such as life span or age at onset of chronic disease, suggest that such traits are typically affected by a large number of small-effect alleles. Individually such alleles have little predictive values, therefore they were usually excluded from further analyses. The results of our study strongly suggest that the alleles with small individual effects on longevity may jointly influence life span so that the resulting influence can be both substantial and significant. We show that this joint influence can be described by a relatively simple "genetic dose - phenotypic response" relationship.
复杂性状的全基因组关联研究结果，如寿命或慢性病发病年龄，表明这些性状通常受大量小效应等位基因影响。单个此类等位基因几乎没有预测价值，因此通常会被排除在进一步分析之外。我们的研究结果有力地表明，对寿命有小的个体效应的等位基因可能共同影响寿命，从而产生的影响可能既显著又重要。我们表明，这种共同影响可以用一个相对简单的“遗传剂量-表型反应”关系来描述。
