Mitochondrial superoxide: a key player in Alzheimer's disease.
作者信息
Massaad Cynthia A, Pautler Robia G, Klann Eric
机构信息
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.
出版信息
Aging (Albany NY). 2009 Sep 14;1(9):758-61. doi: 10.18632/aging.100088.
Abstract
摘要
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本文引用的文献
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Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13576-81. doi: 10.1073/pnas.0902714106. Epub 2009 Aug 3.
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Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition.线粒体二氢硫辛酰基琥珀酰转移酶缺陷加速了淀粉样蛋白沉积转基因小鼠模型中的淀粉样蛋白病理和记忆缺陷。
Free Radic Biol Med. 2009 Oct 1;47(7):1019-27. doi: 10.1016/j.freeradbiomed.2009.07.008. Epub 2009 Jul 22.
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An attempt to prevent senescence: a mitochondrial approach.一种预防衰老的尝试：线粒体途径。
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Biochemistry (Mosc). 2008 Dec;73(12):1317-28. doi: 10.1134/s0006297908120043.
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 3. Inhibitory effect of SkQ1 on tumor development from p53-deficient cells.线粒体靶向的质体醌衍生物作为中断衰老程序执行的工具。3. SkQ1对p53缺陷细胞肿瘤发生的抑制作用。
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Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease.亲环素D缺乏可减轻线粒体和神经元的紊乱，并改善阿尔茨海默病的学习和记忆能力。
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Protective effects of mitochondria-targeted antioxidant SkQ in aqueous and lipid membrane environments.线粒体靶向抗氧化剂SkQ在水相和脂质膜环境中的保护作用。
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