Wu Xinle, Li Yang
Amgen Inc., South San Francisco, CA 94080, USA.
Aging (Albany NY). 2009 Dec 9;1(12):1023-7. doi: 10.18632/aging.100108.
FGF19, FGF21, and FGF23 form a unique subfamily of fibroblast growth factors. Because they contain intra-molecular disulfide bonds and show reduced affinity toward heparan sulfate located in the extracellular space, it is thought that, in contrast to other FGFs, they function as endocrine hormones. FGF23 and its co-receptor alphaKlotho are involved in the control of aging, but it is not known if the same holds true for FGF19, which can also signal through alphaKlotho. However, considerable evidence supports a role for FGF19 in controlling various aspects of metabolism. We have recently fully characterized FGF19/FGFR/co-factor interactions and signaling, and in the current manuscript discuss the contribution of the FGF19/FGFR4 axis to bile acid and glucose regulation.
成纤维细胞生长因子19（FGF19）、成纤维细胞生长因子21（FGF21）和成纤维细胞生长因子23（FGF23）构成了成纤维细胞生长因子的一个独特亚家族。由于它们含有分子内二硫键，且对位于细胞外空间的硫酸乙酰肝素的亲和力降低，因此人们认为，与其他成纤维细胞生长因子不同，它们作为内分泌激素发挥作用。FGF23及其共受体α-klotho参与衰老的调控，但FGF19是否也如此尚不清楚，FGF19也可通过α-klotho进行信号传导。然而，大量证据支持FGF19在控制代谢的各个方面发挥作用。我们最近全面表征了FGF19/成纤维细胞生长因子受体（FGFR）/辅助因子的相互作用和信号传导，并在本手稿中讨论了FGF19/FGFR4轴对胆汁酸和葡萄糖调节的作用。
