代谢性成纤维细胞生长因子（FGFs）：能量稳态的调节因子
Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis.
作者信息
Markan Kathleen R, Potthoff Matthew J
机构信息
Department of Pharmacology and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Department of Pharmacology and University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
出版信息
Semin Cell Dev Biol. 2016 May;53:85-93. doi: 10.1016/j.semcdb.2015.09.021. Epub 2015 Sep 30.
The metabolic fibroblast growth factors (FGFs), FGF1, FGF15/19, and FGF21 differ from classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient availability. These unique mediators of metabolism regulate a number of physiological processes which contribute to their potent pharmacological properties. Administration of pharmacological doses of these FGFs causes weight loss, increases energy expenditure, and improves carbohydrate and lipid metabolism in obese animal models. However, many questions remain regarding the precise molecular and physiological mechanisms governing the effects of individual metabolic FGFs. Here we review the metabolic actions of FGF1, FGF15/19, and FGF21 while providing insights into their pharmacological effects by examining known biological functions.
代谢性成纤维细胞生长因子（FGFs），即FGF1、FGF15/19和FGF21，与经典FGFs不同，它们能根据营养物质供应的波动来调节能量平衡。这些独特的代谢调节因子调控着许多生理过程，这也造就了它们强大的药理特性。在肥胖动物模型中，给予这些FGFs的药理剂量会导致体重减轻、能量消耗增加，并改善碳水化合物和脂质代谢。然而，关于单个代谢性FGFs作用的精确分子和生理机制，仍存在许多问题。在此，我们综述FGF1、FGF15/19和FGF21的代谢作用，同时通过研究已知的生物学功能来深入了解它们的药理作用。
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