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维生素 C 在癌症治疗中的前景。

The prospects of vitamin C in cancer therapy.

机构信息

Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine, Seoul 110-744, Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea.

出版信息

Immune Netw. 2009 Oct;9(5):147-52. doi: 10.4110/in.2009.9.5.147. Epub 2009 Oct 30.

DOI:10.4110/in.2009.9.5.147
PMID:20157602
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2816948/
Abstract

Ascorbate (vitamin C) is a cofactor for a number of metabolic enzymes and is an indisputable essential vitamin C for humans. However, the potential of ascorbate as an anticancer agent has been a topic of controversy. A number of previous reports have addressed both positive aspects and limitations of ascorbate in cancer therapy. In this review, we briefly summarize the potential antitumor effects of ascorbate and its prospects for clinical use.

摘要

抗坏血酸（维生素 C）是许多代谢酶的辅助因子，也是人类不可争议的必需维生素 C。然而，抗坏血酸作为抗癌剂的潜力一直是一个有争议的话题。许多先前的报告都探讨了抗坏血酸在癌症治疗中的积极方面和局限性。在这篇综述中，我们简要总结了抗坏血酸的潜在抗肿瘤作用及其临床应用前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ae/2816948/79ceb5d4f863/in-9-147-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ae/2816948/8c4c52b80954/in-9-147-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ae/2816948/df51c6f6cdf4/in-9-147-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ae/2816948/b96e813c4df2/in-9-147-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ae/2816948/7382b8eb53f8/in-9-147-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ae/2816948/79ceb5d4f863/in-9-147-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ae/2816948/8c4c52b80954/in-9-147-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ae/2816948/df51c6f6cdf4/in-9-147-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ae/2816948/b96e813c4df2/in-9-147-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ae/2816948/7382b8eb53f8/in-9-147-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94ae/2816948/79ceb5d4f863/in-9-147-g005.jpg

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High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer.大剂量维生素C（抗坏血酸）疗法用于晚期癌症患者的治疗。
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Vitamin C inhibits p53-induced replicative senescence through suppression of ROS production and p38 MAPK activity.
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Iran J Pharm Res. 2021 Winter;20(1):105-117. doi: 10.22037/ijpr.2020.112373.13715.
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Antioxidant vitamins promote anticancer effects on low-concentration methotrexate-treated glioblastoma cells via enhancing the caspase-3 death pathway.抗氧化维生素通过增强半胱天冬酶-3死亡途径，对低浓度甲氨蝶呤处理的胶质母细胞瘤细胞产生抗癌作用。
Food Sci Nutr. 2021 May 1;9(6):3308-3316. doi: 10.1002/fsn3.2298. eCollection 2021 Jun.
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