Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B. 653, 84105, Beer Sheva, Israel.
Rheumatol Int. 2010 Jun;30(8):1131-5. doi: 10.1007/s00296-010-1372-y. Epub 2010 Feb 16.
The objective of this study is to evaluate the association between radiographic hand osteoarthritis and serum level of osteocalcin. The study population comprised Chuvashians (285 males, age 47.38 +/- 16.79; 265 females, age 48.55 +/- 15.94 years). OA was evaluated for 14 joints of each hand using Kellgren and Lawrence (K-L), joint space narrowing (JSN) and osteophytes (OS) scores. Plasma-intact osteocalcin was measured in 550 individuals by immunoradiometric assay using ELSA-OSTEO kit. Statistical analyses included multiple linear and logistic regressions. 51.64% of studied individuals had at least one finger joint affected at K-L > or = 2 level. JSN at the level > or = 2 was found in 9.82% and OS > or = 2 was found in 35.09% of the studied individuals. Osteocalcin showed a modest, but statistically significant, association with the number of affected joints according the K-L scale (beta = 0.082, p = 0.015), JSN scale (beta = 0.097, p = 0.025) and OS scale (beta = 0.078, p = 0.029). No significant association was found between the presence of at least one affected joint (K-L > or = 2 or OS > or = 2) and serum level of osteocalcin. Presence of at least one joint with space narrowing > or = 2 was significantly associated with serum level of osteocalcin (beta = 0.052, p = 0.023). In this cross-sectional population-based study, we found that serum level of osteocalcin is positively associated with severity of hand OA, measured by K-L, JSN and OS scales.
本研究旨在评估手部放射学骨关节炎与血清骨钙素水平之间的关系。研究人群包括楚瓦什人（男性 285 人，年龄 47.38±16.79 岁；女性 265 人，年龄 48.55±15.94 岁）。使用 Kellgren 和 Lawrence（K-L）、关节间隙狭窄（JSN）和骨赘（OS）评分评估每只手的 14 个关节的 OA。使用 ELSA-OSTEO 试剂盒通过免疫放射测定法测量 550 名个体的血浆完整骨钙素。统计分析包括多元线性和逻辑回归。研究中 51.64%的个体至少有一个手指关节受累，K-L 分级≥2 级。在研究人群中，9.82%的个体发现 JSN 分级≥2 级，35.09%的个体发现 OS 分级≥2 级。骨钙素与 K-L 分级（β=0.082，p=0.015）、JSN 分级（β=0.097，p=0.025）和 OS 分级（β=0.078，p=0.029）的受累关节数呈中度但具有统计学意义的相关性。未发现至少一个受累关节（K-L≥2 或 OS≥2）与血清骨钙素水平之间存在显著相关性。至少有一个关节存在狭窄（≥2 级）与血清骨钙素水平显著相关（β=0.052，p=0.023）。在这项基于人群的横断面研究中，我们发现血清骨钙素水平与手部 OA 的严重程度呈正相关，通过 K-L、JSN 和 OS 评分来衡量。
