Komatsu Aiko, Node Koichi
Department of Cardiovascular and Renal Medicine, Saga University.
Nihon Rinsho. 2010 Feb;68(2):294-8.
Peroxisome proliferator-activated receptor (PPAR) gamma is a nuclear receptor and ligand-activated transcription factor which plays important roles in the control of energy balance. The thiazolidinediones (TZDs), in use as an insulin-sensitizing agent, are well known as the PPARgamma agonist. Recent studies reported that PPARgamma agonists involve in lipid metabolism through regulating genes including lipoprotein lipase, CD36, and ABCA1. Some clinical trials have been shown that TZD decreased serum levels of LDL-cholesterol and triglycerides and increased serum levels of HDL-cholesterol in type 2 diabetes. In addition, activation of PPARgamma is implicated in the regulation of endothelial function, proliferation and migration of vascular smooth muscle cells, and activation of macrophages.
过氧化物酶体增殖物激活受体（PPAR）γ是一种核受体和配体激活的转录因子，在能量平衡的控制中发挥重要作用。噻唑烷二酮类药物（TZDs）作为一种胰岛素增敏剂，是众所周知的PPARγ激动剂。最近的研究报道，PPARγ激动剂通过调节包括脂蛋白脂肪酶、CD36和ABCA1在内的基因参与脂质代谢。一些临床试验表明，TZDs可降低2型糖尿病患者的低密度脂蛋白胆固醇和甘油三酯血清水平，并提高高密度脂蛋白胆固醇血清水平。此外，PPARγ的激活与内皮功能的调节、血管平滑肌细胞的增殖和迁移以及巨噬细胞的激活有关。
