Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
Org Lett. 2010 Mar 19;12(6):1220-3. doi: 10.1021/ol9029758.
A new class of structurally rigid tricyclic amphibian chiral catalyst was rationally designed based on the hexahydropyrrolo[2,3-b]indole skeleton as a new type of chemzyme. This new type of chemzyme possesses a structurally rigid tricyclic skeleton and a chiral pocket which provides a well-organized chiral environment for asymmetric induction, as well as a hydrophobic pocket to enable organocatalytic reactions to proceed smoothly both in organic solvents and in water.
基于六氢吡咯并[2,3-b]吲哚骨架，设计了一类新型结构刚性三环手性催化剂作为新型化学酶。这种新型化学酶具有结构刚性的三环骨架和手性口袋，为不对称诱导提供了一个组织良好的手性环境，同时还有一个疏水口袋，使有机催化反应能够在有机溶剂和水中顺利进行。
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