埃兹蛋白（Ezrin）和磷酸化埃兹蛋白（pEzrin）在胰腺导管腺癌中的表达。
Expression of Ezrin and phosphorylated Ezrin (pEzrin) in pancreatic ductal adenocarcinoma.
作者信息
Cui Yazhou, Li Tianliang, Zhang Denglu, Han Jinxiang
机构信息
Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Key Laboratory of Ministry of Health for Biotech-Drug, Key Laboratory for Modern Medicine and Technology of Shandong Province, Jinan, China.
出版信息
Cancer Invest. 2010 Mar;28(3):242-7. doi: 10.3109/07357900903124498.
It has been suggested that ezrin activation plays a key role in the regulation of cancer metastasis. In this study, we immunohistochemically investigated the expression patterns of total ezrin and its two phosphorylated forms, pEzrin(- Thr567) and pEzrin(- Tyr353), in 66 samples of invasive pancreatic carcinomas and 11 samples of normal pancreas tissues. Positive expressions of ezrin and pEzrin(- Thr567) were detected in most PDAC tissues, significantly higher than that of pEzrin(- Tyr353). Furthermore, overexpression of pEzrin(- Tyr353) in pancreatic cancers was associated with positive lymph node metastasis, less differentiation, pAkt overexpression, and shorter survival times. pEzrin(- Tyr353) may be a potent prognosis predictor for pancreatic cancer.
有人提出埃兹蛋白激活在癌症转移调控中起关键作用。在本研究中，我们采用免疫组织化学方法调查了66例浸润性胰腺癌样本和11例正常胰腺组织样本中总埃兹蛋白及其两种磷酸化形式pEzrin（-Thr567）和pEzrin（-Tyr353）的表达模式。在大多数胰腺癌组织中检测到埃兹蛋白和pEzrin（-Thr567）的阳性表达，显著高于pEzrin（-Tyr353）。此外，胰腺癌中pEzrin（-Tyr353）的过表达与阳性淋巴结转移、低分化、pAkt过表达及较短生存时间相关。pEzrin（-Tyr353）可能是胰腺癌的一个有力预后预测指标。
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