Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Patiala [Punjab] 147 002, India.
Curr Drug Deliv. 2010 Apr;7(2):152-61. doi: 10.2174/156720110791011783.
In the past years, alternative pharmaceutical formulations of anti-cancer agents have been investigated in order to improve conventional chemotherapy treatment. In conventional/current therapy oral tablet, capsule and injectable formulations are used for anti-cancer drugs delivery. These formulations associated with problems like severe toxic side effects on healthy organs, difficulties in clinical administration, drug resistance and limited access of the drug to the tumor sites suggested the need to focus on site specific controlled drug delivery systems. Novel drug delivery systems are capable of controlling the rate of drug delivery, sustaining the duration of therapeutic activity and targeting the drug to the disease tissue leading to better therapeutic effect with minimum side effects. In this review, we have explored the literature related to recent development in delivery of anti-cancer drugs identify problems in present conventional chemotherapy and detailed newer approaches and future development in the delivery of anti-cancer drugs.
在过去的几年中，人们研究了抗癌药物的替代药物制剂，以改善常规化疗治疗。在常规/当前的治疗中，口服片剂、胶囊和注射剂用于抗癌药物的输送。这些制剂与严重的毒副作用、临床给药困难、耐药性以及药物向肿瘤部位的有限传递等问题相关，这表明需要关注靶向特定部位的药物控释系统。新型药物传递系统能够控制药物的释放速度、维持治疗活性的持续时间，并将药物靶向疾病组织，从而在最小的副作用下实现更好的治疗效果。在本综述中，我们探讨了与抗癌药物传递方面的最新进展相关的文献，确定了目前常规化疗中存在的问题，并详细介绍了抗癌药物传递方面的新方法和未来发展。
