Dibrugarh University, Dibrugarh, Assam-786004, India.
Curr Drug Deliv. 2010 Apr;7(2):162-7. doi: 10.2174/156720110791011800.
Water soluble polysaccharides are most effective oncotic agents which are used for treatment of intravascular volume deficiency. Nowadays, they are used as basic material for plasma volume expander. Plasma volume expander based on starch has lower tendency to remain in any major organ of body in comparison to other plasma volume expander. Branched component of starch amylopectin is very similar in structure to glycogen, the reserve polysaccharides of animal; for all this reason starch is compatible with body tissues. Physicochemical properties of raw starch and amylopectin, isolated from Assam Bora rice were characterized for use as plasma volume expander. Characterization involves the determination of ash value, weight average molecular mass, viscosity and resistance towards enzymatic (amylase) hydrolysis. Amylose content was almost negligible. The X-ray diffraction pattern of Assam Bora rice starch was typically A type. High degree of crystallinity of Assam Bora rice starch reflects its resistance towards enzymatic hydrolysis which is of therapeutic advantage for using it as a plasma volume expander.
水溶性多糖是最有效的胶体渗透压药物，用于治疗血管内容量不足。如今，它们被用作血浆容量扩充剂的基本材料。与其他血浆容量扩充剂相比，基于淀粉的血浆容量扩充剂在体内任何主要器官中残留的倾向较低。淀粉支链成分支链淀粉在结构上与动物的储备多糖糖原非常相似；出于所有这些原因，淀粉与身体组织相容。为用作血浆容量扩充剂，对阿萨姆博拉大米中原淀粉和支链淀粉的理化性质进行了表征。表征包括灰分值、重均分子量、粘度以及对酶（淀粉酶）水解的抗性的测定。直链淀粉含量几乎可以忽略不计。阿萨姆博拉大米淀粉的 X 射线衍射图谱为典型的 A 型。阿萨姆博拉大米淀粉的高结晶度反映了其对酶水解的抵抗力，这对于将其用作血浆容量扩充剂具有治疗优势。
