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使用来自……的天然和改性淀粉制备血浆容量扩充剂及其研发

Formulation and development of plasma volume expander using natural and modified starch from .

作者信息

Thombre Nilima A, Vishwakarma Ajit V, Jadhav Trupti S, Kshirsagar Sanjay J

机构信息

Department of Quality Assurance Techniques, MET's Institute of Pharmacy, Nashik, Maharashtra, India.

出版信息

Int J Pharm Investig. 2016 Oct-Dec;6(4):207-217. doi: 10.4103/2230-973X.195930.

DOI:10.4103/2230-973X.195930
PMID:28123990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5204252/
Abstract

BACKGROUND

To formulation and development of plasma volume expander (PVE) by using natural and modified starch from . The function of blood circulation is to provide the needs of the body tissues and to maintain an appropriate environment in all tissue fluids of the body for the optimal survival and functions of the cells. Rapid restoration of the blood volume is necessary to decrease reduction in the amount of the blood. The PVEs are isotonic colloidal solutions, act by increasing the osmotic pressure of the intravascular compartment, which leads to the influx of the interstitial fluids through the capillary pore which, in turn, leads to the increase in the volume of the blood. Therefore, there is a need to discover the PVE with less side effects. The main aim of the present study is to use amylopectin as PVEs, fractionated from natural and modified starch obtained from .

METHODS

The starch extracted from the normal grains and the tubers of potatoes was selected for the production of starch. Statistical analysis includes characterization that involves viscosity studies, plasma-product interaction, osmotic pressure detection, molecular weight-viscosity relationship, determination of weight average molecular weight, enzymatic interaction, and characterization such as toxicity studies and the effect of the products on the blood coagulation. The isolated starch and fractionated amylopectin were analyzed for the physicochemical characteristics.

RESULT AND CONCLUSION

The amylopectin fractionated from isolated starch from grains and tubers of potatoes can be used as PVE, as per the outcome of the study.

摘要

背景

利用从……获得的天然和改性淀粉来制备和开发血浆容量扩充剂（PVE）。血液循环的功能是满足身体组织的需求，并在身体所有组织液中维持适当的环境，以确保细胞的最佳存活和功能。迅速恢复血容量对于减少血液量的降低是必要的。血浆容量扩充剂是等渗胶体溶液，其作用是增加血管内 compartment 的渗透压，这会导致间质液通过毛细血管孔流入，进而导致血液量增加。因此，需要发现副作用较小的血浆容量扩充剂。本研究的主要目的是使用从……获得的天然和改性淀粉中分离出的支链淀粉作为血浆容量扩充剂。

方法

选择从正常谷物和土豆块茎中提取的淀粉来生产淀粉。统计分析包括涉及粘度研究、血浆 - 产品相互作用、渗透压检测、分子量 - 粘度关系、重均分子量测定、酶相互作用的表征，以及诸如毒性研究和产品对血液凝固影响的表征。对分离出的淀粉和分级支链淀粉进行理化特性分析。

结果与结论

根据研究结果，从谷物和土豆块茎中分离出的淀粉中分级得到的支链淀粉可作为血浆容量扩充剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbe/5204252/82c704e7b002/IJPI-6-207-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbe/5204252/d9f6f10a8a60/IJPI-6-207-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbe/5204252/6866c643c993/IJPI-6-207-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbe/5204252/0e7b79102b86/IJPI-6-207-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbe/5204252/2958c3393008/IJPI-6-207-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbe/5204252/82c704e7b002/IJPI-6-207-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbe/5204252/d9f6f10a8a60/IJPI-6-207-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbe/5204252/6866c643c993/IJPI-6-207-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbe/5204252/0e7b79102b86/IJPI-6-207-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbe/5204252/2958c3393008/IJPI-6-207-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cbe/5204252/82c704e7b002/IJPI-6-207-g009.jpg

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本文引用的文献

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Evaluation of Assam Bora rice starch as plasma volume expander by polymer analysis.
聚合物分析评估阿萨姆博拉米淀粉作为血浆容量扩充剂。
Curr Drug Deliv. 2010 Dec;7(5):436-41. doi: 10.2174/156720110793566209.
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Curr Drug Deliv. 2010 Apr;7(2):162-7. doi: 10.2174/156720110791011800.
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