Booth Carmen J, Brooks Marjory B, Rockwell Sara
Yale University School of Medicine, New Haven, Connecticut, USA.
Comp Med. 2010 Feb;60(1):25-30.
Here we describe a series of cases of spontaneous coagulopathy in a colony of inbred WAG/RijYcb (WAG/RijY) rats. This strain previously had been bred at our institution without symptomatology for several decades. The index case was a 10-wk-old male rat that developed a large hematoma at a subcutaneous injection site. Clinicopathologic findings included a decreased RBC count, decreased hematocrit, decreased hemoglobin concentration, normal PT, and prolonged (50% to 70%) aPTT (52 s; reference, 15 to 33 s). Examination of additional WAG/RijY rats that died unexpectedly or had clinical signs of bleeding in the absence of experimental manipulation also revealed normal PT and prolonged aPTT. Histologic examinations of tissues from all rats were unremarkable except for severe acute focally extensive hemorrhage corresponding to the macroscopic findings of acute hemorrhage. Furthermore the aPTT in 8 clinically normal adult rats and 8 clinically normal 4-wk-old WAG/RijY littermates of both sexes was prolonged. We conclude that these WAG/RijY rats have an inherited defect in the intrinsic coagulation pathway.
在此，我们描述了近交系WAG/RijYcb（WAG/RijY）大鼠群体中一系列自发性凝血病病例。该品系此前在我们机构繁殖了数十年，未出现症状。首例病例是一只10周龄雄性大鼠，其皮下注射部位出现了一个大血肿。临床病理检查结果包括红细胞计数减少、血细胞比容降低、血红蛋白浓度降低、凝血酶原时间正常以及活化部分凝血活酶时间延长（50%至70%）（52秒；参考值为15至33秒）。对其他意外死亡或在无实验操作情况下有出血临床症状的WAG/RijY大鼠进行检查，也发现凝血酶原时间正常而活化部分凝血活酶时间延长。除了与急性出血宏观表现相对应的严重急性局灶性广泛出血外，所有大鼠组织的组织学检查均无异常。此外，8只临床正常的成年大鼠和8只临床正常的4周龄WAG/RijY同窝仔鼠（雌雄均有）的活化部分凝血活酶时间也延长。我们得出结论，这些WAG/RijY大鼠在内源性凝血途径存在遗传性缺陷。
