Booth C J, Sundberg J P
BASF Bioresearch Corporation, Worcester, Massachusetts, USA.
Lab Anim Sci. 1995 Oct;45(5):497-502.
Hemangiomas and hemangiosarcomas are rare, naturally developing tumors of blood vessels. In a retrospective study covering a period of 57 contiguous months between 1986 and 1991, four cavernous hemangiomas, eight capillary hemangiomas, and three hemangiosarcomas developed spontaneously in A/J, BALB/cJ, BALB/cByJ, C57BL/6J, NU/J, and 129/SvJ inbred mouse strains. When data were correlated to actual numbers of each sex in the colony, no sexual dimorphism was determined. At the time of submission, mice ranged in age from 100 to 434 days, with a mean of 217 days. Tumors principally affected the skin but were also diagnosed in the seminal vesicles, liver, muscle tissue, and cerebellum. Immunohistochemistry, with antisera directed against human von Willebrand factor (factor VIII-related antigen) as an endothelial cell marker, labeled mouse endothelial cells inconsistently. A monoclonal antibody directed against the smooth muscle actin isoform, but not the sarcomeric muscle actin isoform, outlined vascular structures in tumors and normal vascular smooth muscle in adjacent normal tissues.
血管瘤和血管肉瘤是罕见的、自然发生的血管肿瘤。在一项涵盖1986年至1991年连续57个月的回顾性研究中，A/J、BALB/cJ、BALB/cByJ、C57BL/6J、NU/J和129/SvJ近交系小鼠自发出现了4例海绵状血管瘤、8例毛细血管瘤和3例血管肉瘤。当将数据与群体中每种性别的实际数量相关联时，未发现性别差异。在提交时，小鼠年龄在100至434天之间，平均为217天。肿瘤主要影响皮肤，但也在精囊、肝脏、肌肉组织和小脑中被诊断出。以针对人血管性血友病因子（因子VIII相关抗原）的抗血清作为内皮细胞标记物进行免疫组织化学检测，对小鼠内皮细胞的标记并不一致。一种针对平滑肌肌动蛋白异构体而非肌节肌动蛋白异构体的单克隆抗体勾勒出肿瘤中的血管结构以及相邻正常组织中的正常血管平滑肌。
