Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Psychiatr Clin North Am. 2010 Mar;33(1):15-34. doi: 10.1016/j.psc.2009.12.005.
Given the potential benefits of gene identification in psychiatry, genetic epidemiology has become a mainstream discipline within the field. This article discusses the main tools for gene discovery. The focus is on the designs and analytic approaches for each of these methods. Because most gene discovery has now moved to genetic association studies, and most recently to genome-wide association studies, the focus is on methods for this design. Also highlighted are the current challenges of genetic epidemiology as a prelude to future approaches that may be applied to psychiatric disorders in the coming years.
鉴于基因识别在精神病学中的潜在益处，遗传流行病学已成为该领域的主流学科。本文讨论了基因发现的主要工具。重点是这些方法中的每一种的设计和分析方法。由于大多数基因发现现在已经转移到基因关联研究，最近又转移到全基因组关联研究，因此重点是这种设计的方法。本文还突出了遗传流行病学目前面临的挑战，为未来可能应用于未来几年精神疾病的方法奠定了基础。
