BCL-2 家族团聚。
The BCL-2 family reunion.
机构信息
Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
出版信息
Mol Cell. 2010 Feb 12;37(3):299-310. doi: 10.1016/j.molcel.2010.01.025.
Abstract
B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.
摘要
B 细胞慢性淋巴细胞白血病/淋巴瘤-2（BCL-2）及其相关蛋白构成了 BCL-2 家族蛋白，它们最初的特征是在控制外线粒体膜完整性和细胞凋亡方面的作用。目前的观察结果将 BCL-2 家族的功能扩展到包括许多细胞途径。在这里，我们将讨论 BCL-2 家族在这些途径中的作用机制和功能，重点介绍 BCL-2 家族在细胞命运决定中的复杂整合和调节。
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