在小鼠中模拟抗体增强登革病毒感染和疾病：保护还是发病机制？
Modeling antibody-enhanced dengue virus infection and disease in mice: protection or pathogenesis?
机构信息
Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Cell Host Microbe. 2010 Feb 18;7(2):85-6. doi: 10.1016/j.chom.2010.02.004.
While antibodies play an important protective role during dengue virus infection, they have also been linked to more severe clinical outcomes. In this issue of Cell Host & Microbe, Zellweger and colleagues (Zellweger et al., 2010) describe the development of a murine model of antibody-enhanced dengue virus infection that provides a formal link between immune enhancement and severe disease.
虽然抗体在登革热病毒感染期间发挥了重要的保护作用，但它们也与更严重的临床结果有关。在本期的《细胞宿主与微生物》杂志上，Zellweger 及其同事（Zellweger 等人，2010）描述了一种增强型登革热病毒感染的小鼠模型的开发，该模型为免疫增强与严重疾病之间建立了正式联系。
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