Viral Pathogenesis Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Cell Host Microbe. 2010 Feb 18;7(2):85-6. doi: 10.1016/j.chom.2010.02.004.
While antibodies play an important protective role during dengue virus infection, they have also been linked to more severe clinical outcomes. In this issue of Cell Host & Microbe, Zellweger and colleagues (Zellweger et al., 2010) describe the development of a murine model of antibody-enhanced dengue virus infection that provides a formal link between immune enhancement and severe disease.
虽然抗体在登革热病毒感染期间发挥了重要的保护作用，但它们也与更严重的临床结果有关。在本期的《细胞宿主与微生物》杂志上，Zellweger 及其同事（Zellweger 等人，2010）描述了一种增强型登革热病毒感染的小鼠模型的开发，该模型为免疫增强与严重疾病之间建立了正式联系。
