共餐：宿主-寄生虫相互作用的代谢组学。
Eating at the table of another: metabolomics of host-parasite interactions.
机构信息
Lewis-Sigler Institute for Integrative Genomics, Princeton University, NJ 08544, USA.
出版信息
Cell Host Microbe. 2010 Feb 18;7(2):90-9. doi: 10.1016/j.chom.2010.01.008.
Abstract
The application of metabolomics, the global analysis of metabolite levels, to the study of protozoan parasites has become an important tool for understanding the host-parasite relationship and holds promise for the development of direly needed therapeutics and improved diagnostics. Research advances over the past decade have opened the door for a systems biology approach to protozoan parasites with metabolomics, providing a crucial readout of metabolic activity. In this review, we highlight recent metabolomic approaches to protozoan parasites, including metabolite profiling, integration with genomics, transcription, and proteomic analysis, and the use of metabolic fingerprints for the diagnosis of parasitic infections.
摘要
代谢组学的应用，即代谢物水平的全局分析，已成为研究原生动物寄生虫的重要工具，有助于了解宿主-寄生虫关系，并有望开发急需的治疗方法和改进的诊断方法。过去十年的研究进展为采用代谢组学方法研究原生动物寄生虫打开了大门，为代谢活性提供了关键的检测手段。在这篇综述中，我们重点介绍了原生动物寄生虫的最新代谢组学方法，包括代谢物谱分析、与基因组学、转录组和蛋白质组学分析的整合，以及代谢指纹图谱在寄生虫感染诊断中的应用。
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