Wu Jun, Xiao Yun, Wang Wei, Lu Dong-feng, He Zhao-chu, Chen Ming-sheng
Department of Cardiology, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2010 Feb;30(2):275-7.
To investigate the effect of hyperlipidemia on vasa vasorum and vascular endothelial growth factor (VEGF) and study the role of vasa vasorum in arteriosclerosis.
Thirty SD rats were randomized into normal control, hyperlipidemic and simvastatin treatment groups (n=10). In simvastatin group, hyperlipidemia was induced by a 4-week administration of atherogenic diet followed by a 16-week treatment with simvastatin at the daily dose of 10 mg/kg, and the rats in hyperlipidemic rats received no treatment. The changes in the aorta and vasa vasorum were examined, and serum lipid concentration and VEGF and NO levels were measured.
Compared with the control group, the hyperlipidemic rats showed significantly thickened intima and media aorta and increased vasa vasorum density with lowered NO level, but VEGF underwent no significant changes. Simvastatin treatment significantly reduced the thickness of the intima and media aorta and increased vasa vasorum density in comparison with those in hyperlipidemic group. Simvastatin treatment also significantly increased VEGF and NO levels and a positive correlation was noted between their levels.
Hyperlipidemia can impair the vasa vasorum and aortic endothelial function. Simvastatin increases VEGF and NO and promotes neogenesis of the vasa vasorum for the benefit of the aortic function.
探讨高脂血症对血管滋养血管及血管内皮生长因子（VEGF）的影响，并研究血管滋养血管在动脉粥样硬化中的作用。
将30只SD大鼠随机分为正常对照组、高脂血症组和辛伐他汀治疗组（n = 10）。辛伐他汀组先给予致动脉粥样硬化饮食4周诱导高脂血症，随后给予辛伐他汀每日剂量10 mg/kg治疗16周，高脂血症组大鼠不进行治疗。检查主动脉和血管滋养血管的变化，并测量血脂浓度、VEGF和NO水平。
与对照组相比，高脂血症大鼠主动脉内膜和中膜明显增厚，血管滋养血管密度增加，NO水平降低，但VEGF无明显变化。与高脂血症组相比，辛伐他汀治疗显著降低了主动脉内膜和中膜厚度，增加了血管滋养血管密度。辛伐他汀治疗还显著提高了VEGF和NO水平，且两者水平呈正相关。
高脂血症可损害血管滋养血管和主动脉内皮功能。辛伐他汀可增加VEGF和NO，并促进血管滋养血管新生，从而改善主动脉功能。
