The E2D2 model: a dynamic approach to cancer prevention interventions.

The E2D2 model is a systematic, evidence-informed approach to designing comprehensive and strategic interventions focused on cancer prevention, with potential applications to the broader chronic disease community. The model was developed using an omnibus approach to account for multilevel influences and determinants of individual and population health, quality of life, and cancer risk. It is focused on the four pillars of health promotion and intervention practice (evidence, evaluation, development, and delivery) and moves through three fundamental phases: identification of risk factors and sensitizing concepts; mediating mechanisms and modifiable contexts; and program development, delivery, and evaluation. Distinguished from other models in the health promotion field, the E2D2 model is designed to be both sequential and feedback oriented, which allows for the emergence of new evidence, procedural revisions, and knowledge exchange to occur during any of its phases.