Department of Medicine, Baylor College of Medicine, One Baylor Plaza, BCM 285 Suite 535E, Houston, TX 77030, USA.
Proc Am Thorac Soc. 2010 Feb;7(1):22-8. doi: 10.1513/pats.200909-103JS.
Autophagy (self-eating) is an evolutionary conserved simple process by which cells target their own cellular organelles and long-lived proteins for degradation. Recently, this simple ancient process has proved to be involved in many biological aspects, including host defense, cell survival and death, innate and adaptive immunity, and cancer. The implications of aberrant regulation of autophagy in human diseases are just beginning to unravel. This is a brief review of recent progress in the association of autophagy with innate and adaptive immunity relevant to lung biology and disease.
自噬（自我吞噬）是一种进化上保守的简单过程，细胞通过该过程靶向自身的细胞细胞器和长寿蛋白进行降解。最近，这个简单的古老过程被证明涉及许多生物学方面，包括宿主防御、细胞存活和死亡、先天和适应性免疫以及癌症。自噬异常调节与人类疾病的关系才刚刚开始被揭示。本文简要综述了自噬与先天和适应性免疫相关的最新进展，这些进展与肺生物学和疾病有关。
