先天免疫和适应性免疫中的自噬作用。
Autophagy in innate and adaptive immunity.
机构信息
Department of Medicine, Baylor College of Medicine, One Baylor Plaza, BCM 285 Suite 535E, Houston, TX 77030, USA.
出版信息
Proc Am Thorac Soc. 2010 Feb;7(1):22-8. doi: 10.1513/pats.200909-103JS.
Abstract
Autophagy (self-eating) is an evolutionary conserved simple process by which cells target their own cellular organelles and long-lived proteins for degradation. Recently, this simple ancient process has proved to be involved in many biological aspects, including host defense, cell survival and death, innate and adaptive immunity, and cancer. The implications of aberrant regulation of autophagy in human diseases are just beginning to unravel. This is a brief review of recent progress in the association of autophagy with innate and adaptive immunity relevant to lung biology and disease.
摘要
自噬（自我吞噬）是一种进化上保守的简单过程，细胞通过该过程靶向自身的细胞细胞器和长寿蛋白进行降解。最近，这个简单的古老过程被证明涉及许多生物学方面，包括宿主防御、细胞存活和死亡、先天和适应性免疫以及癌症。自噬异常调节与人类疾病的关系才刚刚开始被揭示。本文简要综述了自噬与先天和适应性免疫相关的最新进展，这些进展与肺生物学和疾病有关。
相似文献
1
Autophagy in innate and adaptive immunity.先天免疫和适应性免疫中的自噬作用。
Proc Am Thorac Soc. 2010 Feb;7(1):22-8. doi: 10.1513/pats.200909-103JS.
2
Toll-like receptors in control of immunological autophagy.Toll样受体对免疫自噬的调控
Cell Death Differ. 2009 Jul;16(7):976-83. doi: 10.1038/cdd.2009.40. Epub 2009 May 15.
3
Regulation of innate immune responses by autophagy-related proteins.自噬相关蛋白对固有免疫反应的调节。
J Cell Biol. 2010 Jun 14;189(6):925-35. doi: 10.1083/jcb.201002021.
4
Toll-like receptor signaling in the lysosomal pathways.溶酶体途径中的Toll样受体信号传导。
Immunol Rev. 2009 Jan;227(1):203-20. doi: 10.1111/j.1600-065X.2008.00732.x.
5
Immunoamphisomes in dendritic cells amplify TLR signaling and enhance exogenous antigen presentation on MHC-II.树突状细胞中的免疫阿米巴样小体增强 TLR 信号转导并增强 MHC-II 上的外源性抗原呈递。
Autophagy. 2010 Aug;6(6):816-8. doi: 10.4161/auto.6.6.12623. Epub 2010 Aug 9.
6
Noncanonical autophagy: one small step for LC3, one giant leap for immunity.非典型自噬：LC3 的一小步，免疫的一大步。
Curr Opin Immunol. 2014 Feb;26:69-75. doi: 10.1016/j.coi.2013.10.012. Epub 2013 Nov 30.
7
Self-eating and self-defense: autophagy controls innate immunity and adaptive immunity.自噬：自我吞噬与自我防御。自噬调控先天免疫与适应性免疫。
J Leukoc Biol. 2013 Apr;93(4):511-9. doi: 10.1189/jlb.0812389. Epub 2012 Dec 27.
8
Phagosome as the organelle linking innate and adaptive immunity.吞噬体作为连接先天免疫和适应性免疫的细胞器。
Traffic. 2012 Aug;13(8):1053-61. doi: 10.1111/j.1600-0854.2012.01377.x. Epub 2012 Jun 12.
9
Enhancing immunity through autophagy.通过自噬增强免疫力。
Annu Rev Immunol. 2009;27:423-49. doi: 10.1146/annurev.immunol.021908.132537.
10
TLRs/NLRs: Shaping the landscape of host immunity.TLRs/NLRs：塑造宿主免疫的格局。
Int Rev Immunol. 2018 Jan 2;37(1):3-19. doi: 10.1080/08830185.2017.1397656. Epub 2017 Dec 1.
引用本文的文献
1
Lysosomal storage, impaired autophagy and innate immunity in Gaucher and Parkinson's diseases: insights for drug discovery.溶酶体储存、自噬和先天免疫在 Gaucher 和帕金森病中的作用：药物发现的新视角。
Philos Trans R Soc Lond B Biol Sci. 2024 Apr 8;379(1899):20220381. doi: 10.1098/rstb.2022.0381. Epub 2024 Feb 19.
2
Roles of autophagy in killing of mycobacterial pathogens by host macrophages - Effects of some medicinal plants.自噬在宿主巨噬细胞杀灭分枝杆菌病原体中的作用——一些药用植物的影响。
Eur J Microbiol Immunol (Bp). 2024 Feb 13;14(1):26-36. doi: 10.1556/1886.2023.00062. Print 2024 Feb 23.
3
The plant pathogenic bacterium Liberibacter solanacearum induces calcium-regulated autophagy in midgut cells of its insect vector .植物致病细菌番茄韧皮部杆菌在其昆虫载体的中肠细胞中诱导钙调节自噬。
Microbiol Spectr. 2023 Sep 28;11(5):e0130123. doi: 10.1128/spectrum.01301-23.
4
Autophagy inducer rapamycin treatment reduces IFN-I-mediated Inflammation and improves anti-HIV-1 T cell response in vivo.自噬诱导剂雷帕霉素治疗可减少 IFN-I 介导的炎症反应，并改善体内抗 HIV-1 T 细胞反应。
JCI Insight. 2022 Nov 22;7(22):e159136. doi: 10.1172/jci.insight.159136.
5
Cannabidiol modulates expression of type I IFN response genes and HIV infection in macrophages.大麻二酚调节巨噬细胞中 I 型干扰素反应基因和 HIV 感染的表达。
Front Immunol. 2022 Sep 29;13:926696. doi: 10.3389/fimmu.2022.926696. eCollection 2022.
6
Asthma Susceptibility Gene Promotes Autophagy in Human Bronchial Epithelium.哮喘易感性基因促进人支气管上皮细胞自噬。
Am J Respir Cell Mol Biol. 2022 Jun;66(6):661-670. doi: 10.1165/rcmb.2021-0305OC.
7
Autophagy in Tumor Immunity and Viral-Based Immunotherapeutic Approaches in Cancer.肿瘤免疫中的自噬作用和癌症的基于病毒的免疫治疗方法。
Cells. 2021 Oct 6;10(10):2672. doi: 10.3390/cells10102672.
8
Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy.环黄芪醇通过抑制自噬缓解哮喘小鼠的气道炎症。
Mol Med Rep. 2021 Nov;24(5). doi: 10.3892/mmr.2021.12445. Epub 2021 Sep 20.
9
Multiplicity of Glycosphingolipid-Enriched Microdomain-Driven Immune Signaling.糖脂富集微区驱动的免疫信号的多态性。
Int J Mol Sci. 2021 Sep 3;22(17):9565. doi: 10.3390/ijms22179565.
10
Phosphatidic acid-mediated binding and mammalian cell internalization of the Vibrio cholerae cytotoxin MakA.磷脂酸介导的霍乱弧菌细胞毒素 MakA 的结合和哺乳动物细胞内化。
PLoS Pathog. 2021 Mar 18;17(3):e1009414. doi: 10.1371/journal.ppat.1009414. eCollection 2021 Mar.
本文引用的文献
1
RIP kinases at the crossroads of cell death and survival.RIP激酶处于细胞死亡与存活的十字路口。
Cell. 2009 Jul 23;138(2):229-32. doi: 10.1016/j.cell.2009.07.006.
2
Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation.磷酸化驱动的RIP1-RIP3复合物组装调节程序性坏死和病毒诱导的炎症。
Cell. 2009 Jun 12;137(6):1112-23. doi: 10.1016/j.cell.2009.05.037.
3
Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha.受体相互作用蛋白激酶-3决定细胞对肿瘤坏死因子-α的坏死反应。
Cell. 2009 Jun 12;137(6):1100-11. doi: 10.1016/j.cell.2009.05.021.
4
p62 at the crossroads of autophagy, apoptosis, and cancer.p62处于自噬、凋亡和癌症的交叉点。
Cell. 2009 Jun 12;137(6):1001-4. doi: 10.1016/j.cell.2009.05.023.
5
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.RIP3，一种能量代谢调节因子，可将肿瘤坏死因子诱导的细胞死亡从凋亡转变为坏死。
Science. 2009 Jul 17;325(5938):332-6. doi: 10.1126/science.1172308. Epub 2009 Jun 4.
6
Autophagy is essential for mitochondrial clearance in mature T lymphocytes.自噬对于成熟T淋巴细胞中的线粒体清除至关重要。
J Immunol. 2009 Apr 1;182(7):4046-55. doi: 10.4049/jimmunol.0801143.
7
Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells.自噬通过增加小鼠树突状细胞中的肽呈递来增强卡介苗的效力。
Nat Med. 2009 Mar;15(3):267-76. doi: 10.1038/nm.1928. Epub 2009 Mar 1.
8
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway.调控细胞坏死性细胞死亡途径的分子信号网络的鉴定。
Cell. 2008 Dec 26;135(7):1311-23. doi: 10.1016/j.cell.2008.10.044.
9
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.自噬及自噬基因Atg16l1在小鼠和人类肠道潘氏细胞中的关键作用。
Nature. 2008 Nov 13;456(7219):259-63. doi: 10.1038/nature07416. Epub 2008 Oct 5.
10
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance.胸腺上皮细胞中的自噬塑造了T细胞库，对免疫耐受至关重要。
Nature. 2008 Sep 18;455(7211):396-400. doi: 10.1038/nature07208. Epub 2008 Aug 13.
Zotero 插件