• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

RIP激酶处于细胞死亡与存活的十字路口。

RIP kinases at the crossroads of cell death and survival.

作者信息

Declercq Wim, Vanden Berghe Tom, Vandenabeele Peter

机构信息

Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium.

出版信息

Cell. 2009 Jul 23;138(2):229-32. doi: 10.1016/j.cell.2009.07.006.

DOI:10.1016/j.cell.2009.07.006
PMID:19632174
Abstract

Protein kinases of the receptor interacting protein (RIP) family collaborate with death receptor proteins to regulate cell death. Recent studies (Cho et al., 2009; He et al., 2009; Zhang et al., 2009) reveal that the RIP3 kinase functions with RIP1 at the crossroads of apoptosis, necroptosis, and cell survival.

摘要

受体相互作用蛋白(RIP)家族的蛋白激酶与死亡受体蛋白协同作用以调节细胞死亡。最近的研究(赵等人,2009年;何等人,2009年;张等人,2009年)表明,RIP3激酶与RIP1在细胞凋亡、坏死性凋亡和细胞存活的交叉点发挥作用。

相似文献

1
RIP kinases at the crossroads of cell death and survival.RIP激酶处于细胞死亡与存活的十字路口。
Cell. 2009 Jul 23;138(2):229-32. doi: 10.1016/j.cell.2009.07.006.
2
RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review).RIP1/RIP3 调节的坏死性凋亡作为多方面疾病治疗的靶点(综述)。
Int J Mol Med. 2019 Sep;44(3):771-786. doi: 10.3892/ijmm.2019.4244. Epub 2019 Jun 14.
3
Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death.RIP1的协同泛素化和磷酸化调节坏死性细胞死亡。
Cell Death Differ. 2017 Jan;24(1):26-37. doi: 10.1038/cdd.2016.78. Epub 2016 Aug 12.
4
Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway.细胞程序性坏死调控放疗后肿瘤细胞再增殖及其机制研究
J Exp Clin Cancer Res. 2019 Nov 9;38(1):461. doi: 10.1186/s13046-019-1423-5.
5
Connections between various trigger factors and the RIP1/ RIP3 signaling pathway involved in necroptosis.各种触发因素与坏死性凋亡中涉及的RIP1/RIP3信号通路之间的联系。
Asian Pac J Cancer Prev. 2013;14(12):7069-74. doi: 10.7314/apjcp.2013.14.12.7069.
6
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.RIP1 和 RIP3 激酶在 TNF 诱导的细胞坏死中的作用。
Sci Signal. 2010 Mar 30;3(115):re4. doi: 10.1126/scisignal.3115re4.
7
Necroptosis: an emerging form of programmed cell death.细胞程序性坏死:一种新兴的细胞死亡方式。
Crit Rev Oncol Hematol. 2012 Jun;82(3):249-58. doi: 10.1016/j.critrevonc.2011.08.004. Epub 2011 Oct 1.
8
Increased hepatic receptor interacting protein kinase 3 expression due to impaired proteasomal functions contributes to alcohol-induced steatosis and liver injury.蛋白酶体功能受损导致肝脏受体相互作用蛋白激酶3表达增加,这有助于酒精性脂肪变性和肝损伤。
Oncotarget. 2016 Apr 5;7(14):17681-98. doi: 10.18632/oncotarget.6893.
9
RIP1 and RIP3 contribute to shikonin-induced DNA double-strand breaks in glioma cells via increase of intracellular reactive oxygen species.RIP1 和 RIP3 通过增加细胞内活性氧诱导神经胶质瘤细胞中紫草素诱导的 DNA 双链断裂。
Cancer Lett. 2017 Apr 1;390:77-90. doi: 10.1016/j.canlet.2017.01.004. Epub 2017 Jan 17.
10
Necroptosis: Pathway diversity and characteristics.坏死性凋亡:信号通路的多样性与特征
Semin Cell Dev Biol. 2015 Mar;39:56-62. doi: 10.1016/j.semcdb.2015.02.002. Epub 2015 Feb 13.

引用本文的文献

1
Guardian of myelin and neural Integrity: foxo1a through slc7a11 mitigating oxidative damage in myelin.髓鞘和神经完整性的守护者:通过溶质载体家族7成员11(SLC7A11)的叉头框蛋白O1a(FOXO1a)减轻髓鞘中的氧化损伤
Redox Biol. 2025 Jul 12;85:103763. doi: 10.1016/j.redox.2025.103763.
2
Young rat vascular endothelial cells promote neurological recovery of stroke aged rat via HIF-1α.年轻大鼠血管内皮细胞通过低氧诱导因子-1α促进老年中风大鼠的神经功能恢复。
iScience. 2025 Apr 29;28(6):112552. doi: 10.1016/j.isci.2025.112552. eCollection 2025 Jun 20.
3
Necroptosis-Related Gene Signature Predicts Prognosis in Patients with Advanced Ovarian Cancer.
坏死性凋亡相关基因特征预测晚期卵巢癌患者的预后
Cancers (Basel). 2025 Jan 15;17(2):271. doi: 10.3390/cancers17020271.
4
The necroptosis-related lncRNA ENSG00000253385.1 promotes the progression of esophageal squamous cell carcinoma by targeting the miR-16-2-3p/VDAC1 axis.与坏死性凋亡相关的长链非编码RNA ENSG00000253385.1通过靶向miR-16-2-3p/电压依赖性阴离子通道1轴促进食管鳞状细胞癌的进展。
Sci Rep. 2025 Jan 21;15(1):2650. doi: 10.1038/s41598-025-85646-3.
5
The mechanisms behind heatstroke-induced intestinal damage.中暑诱导肠道损伤背后的机制。
Cell Death Discov. 2024 Oct 28;10(1):455. doi: 10.1038/s41420-024-02210-0.
6
Genomic and Transcriptional Analysis of the Necroptosis Pathway Elements RIPK and MLKL in Sea Cucumber, .海参与细胞坏死通路元件 RIPK 和 MLKL 的基因组和转录组分析。
Genes (Basel). 2024 Oct 3;15(10):1297. doi: 10.3390/genes15101297.
7
Identification and validation of a five-necroptosis-related lncRNAs signature for prognostic prediction in hepatocellular carcinoma.用于肝细胞癌预后预测的五个坏死性凋亡相关长链非编码RNA特征的鉴定与验证
Heliyon. 2024 Sep 6;10(18):e37403. doi: 10.1016/j.heliyon.2024.e37403. eCollection 2024 Sep 30.
8
Mitochondrial Quality Control Processes at the Crossroads of Cell Death and Survival: Mechanisms and Signaling Pathways.线粒体质量控制过程在细胞死亡与存活的交汇点:机制与信号通路。
Int J Mol Sci. 2024 Jul 3;25(13):7305. doi: 10.3390/ijms25137305.
9
Mitochondria-Derived Vesicles, Sterile Inflammation, and Pyroptosis in Liver Cancer: Partners in Crime or Innocent Bystanders?肝癌中的线粒体衍生囊泡、无菌性炎症和细胞焦亡:是共犯还是无辜的旁观者?
Int J Mol Sci. 2024 Apr 27;25(9):4783. doi: 10.3390/ijms25094783.
10
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity.肿瘤中的免疫原性细胞死亡:靶向坏死性凋亡诱导抗肿瘤免疫。
Nat Rev Cancer. 2024 May;24(5):299-315. doi: 10.1038/s41568-024-00674-x. Epub 2024 Mar 7.