Declercq Wim, Vanden Berghe Tom, Vandenabeele Peter
Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, 9052 Ghent, Belgium.
Cell. 2009 Jul 23;138(2):229-32. doi: 10.1016/j.cell.2009.07.006.
Protein kinases of the receptor interacting protein (RIP) family collaborate with death receptor proteins to regulate cell death. Recent studies (Cho et al., 2009; He et al., 2009; Zhang et al., 2009) reveal that the RIP3 kinase functions with RIP1 at the crossroads of apoptosis, necroptosis, and cell survival.
受体相互作用蛋白(RIP)家族的蛋白激酶与死亡受体蛋白协同作用以调节细胞死亡。最近的研究(赵等人,2009年;何等人,2009年;张等人,2009年)表明,RIP3激酶与RIP1在细胞凋亡、坏死性凋亡和细胞存活的交叉点发挥作用。