Department of Psychiatry, University of California, San Diego, San Diego, USA.
J Neuropsychiatry Clin Neurosci. 2010 Winter;22(1):30-9. doi: 10.1176/jnp.2010.22.1.30.
The authors aim to investigate brain plasticity and vulnerability through the study of the relationship of age at the time of brain injury and neurocognitive and psychiatric outcome. Children with early stroke performed more poorly compared with children with late stroke in a wide variety of domains including intellectual function, language, memory, visuospatial function, academic function, and psychiatric problems. The exception to this pattern was that children with late stroke performed more poorly in two of three executive function tests. These findings suggest that in children with focal brain injury, as in those with more diffuse brain insults, younger age at injury predicts worse neurocognitive outcomes, although this may not apply to selected executive function outcomes. Adverse psychiatric outcome after early stroke is less direct but is evident in terms of severity in affected cases.
作者旨在通过研究脑损伤发生时的年龄与神经认知和精神预后的关系来探究大脑的可塑性和脆弱性。与晚发性卒中患儿相比，早发性卒中患儿在包括智力、语言、记忆、视空间功能、学业功能和精神问题等各个领域的表现均较差。但这种模式存在一个例外，即晚发性卒中患儿在三项执行功能测试中的两项测试中的表现更差。这些发现表明，在局灶性脑损伤患儿中，与更弥漫性脑损伤患儿一样，损伤发生时年龄越小，神经认知结果越差，尽管这可能不适用于某些特定的执行功能结果。早发性卒中后不良的精神预后并非直接相关，但在受影响病例的严重程度上是显而易见的。
