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A comparison between Skp2 and FOXO1 for their cytoplasmic localization by Akt1.

作者信息

Wang Hongbo, Cui Jinhua, Bauzon Frederick, Zhu Liang

机构信息

Department of Developmental and Molecular Biology, and Medicine, Albert Einstein Cancer Research Center and Liver Research Center, Albert Einstein College of Medicine, Bronx, NY, USA.

出版信息

Cell Cycle. 2010 Mar 1;9(5):1021-2. doi: 10.4161/cc.9.5.10916. Epub 2010 Mar 9.

Abstract
摘要

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本文引用的文献

1
Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.
Nat Cell Biol. 2009 Apr;11(4):397-408. doi: 10.1038/ncb1847. Epub 2009 Mar 8.
2
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.
Nat Cell Biol. 2009 Apr;11(4):420-32. doi: 10.1038/ncb1849. Epub 2009 Mar 8.
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Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.
Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7421-6. doi: 10.1073/pnas.96.13.7421.
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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor.
Cell. 1999 Mar 19;96(6):857-68. doi: 10.1016/s0092-8674(00)80595-4.

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