癫痫脑的高频振荡。
High-frequency oscillations in epileptic brain.
机构信息
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
出版信息
Curr Opin Neurol. 2010 Apr;23(2):151-6. doi: 10.1097/WCO.0b013e3283373ac8.
PURPOSE OF REVIEW
It has been 10 years since pathological high-frequency oscillations (pHFOs) were described in the brain of epileptic animals and patients. This review summarizes progress in research on mechanisms of their generation and potential clinical applications over that period.
RECENT FINDINGS
Initially, pHFOs were recorded with microelectrodes in the hippocampus of rodents and patients with mesial temporal lobe epilepsy (MTLE), but recently pHFOs have also been recorded with clinical depth and grid electrodes in multiple brain areas including the hippocampus and neocortex of patients with different types of epilepsy. One hypothesis is that pHFOs reflect fields of hypersynchronized action potentials (bursts of population spikes) within small discrete neuronal clusters responsible for seizure generation. Studies suggest that pHFOs can be used as a reliable biomarker for epileptogenesis, epileptogenicity, and the delineation of the epileptogenic region.
SUMMARY
Recording of pHFOs with clinical electrodes provides a means for further investigation of their functional role in the epileptic brain and as a potential biomarker of epileptogenesis and epileptogenicity and for presurgical mapping.
目的综述
自病理性高频振荡（pHFO）在癫痫动物和患者的大脑中被描述以来，已经过去了 10 年。本综述总结了在此期间关于其产生机制及其潜在临床应用的研究进展。
最新发现
最初，pHFO 是在啮齿动物的海马体和内侧颞叶癫痫（MTLE）患者的微电极上记录的，但最近也使用临床深度和网格电极在多个脑区记录了 pHFO，包括海马体和不同类型癫痫患者的新皮层。一种假设是，pHFO 反映了负责癫痫发作的小离散神经元簇内超同步动作电位（群体峰爆发）的场。研究表明，pHFO 可用作癫痫发生、致痫性和致痫区域描绘的可靠生物标志物。
总结
使用临床电极记录 pHFO 为进一步研究其在癫痫大脑中的功能作用以及作为癫痫发生和致痫性的潜在生物标志物和术前定位提供了一种手段。
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