局灶性癫痫患者的高频振荡与癫痫发作频率
High frequency oscillations and seizure frequency in patients with focal epilepsy.
作者信息
Zijlmans Maeike, Jacobs Julia, Zelmann Rina, Dubeau François, Gotman Jean
机构信息
Montreal Neurological Institute and Hospital, McGill University, 3801 University Street, Montreal (Québec), Canada H3A 2B4.
出版信息
Epilepsy Res. 2009 Aug;85(2-3):287-92. doi: 10.1016/j.eplepsyres.2009.03.026. Epub 2009 Apr 29.
Abstract
High frequency oscillations (HFOs) have been associated with epileptogenicity. In rats, the extent of HFOs (>200 Hz) is correlated with seizure frequency. We studied whether the same applies to patients with focal epilepsy. Thirty-nine patients with intracerebral EEG sampled at 2000 Hz were studied for interictal ripples (80-250 Hz), fast ripples (FR, 250-500 Hz) and spikes. Seizure frequency before implantation was compared to numbers of channels with HFOs (>1/min). Analyses were repeated for HFO rates of >5, >10 and >20. Separate analyses were done for 25 patients with temporal lobe epilepsy only and for a selection of similar unilateral temporal channels in 12 patients. No linear correlation or trend was found relating the number of channels with HFOs and seizure frequency. There was a linear positive correlation between the number of channels with more than 20 FRs/min and seizure frequency. The hypothesis that the more tissue generating HFOs, the higher the seizure frequency, was not confirmed, though there might be a correlation for high FR rates.
摘要
高频振荡（HFOs）与致痫性有关。在大鼠中，HFOs（>200Hz）的程度与癫痫发作频率相关。我们研究了这是否同样适用于局灶性癫痫患者。对39例以2000Hz采样颅内脑电图的患者进行了发作间期涟漪（80 - 250Hz）、快涟漪（FR，250 - 500Hz）和棘波的研究。将植入前的癫痫发作频率与有HFOs（>1次/分钟）的通道数量进行比较。对HFOs频率>5、>10和>20的情况重复进行分析。仅对25例颞叶癫痫患者以及1,2例患者中选择的类似单侧颞叶通道进行了单独分析。未发现有HFOs的通道数量与癫痫发作频率之间存在线性相关或趋势。每分钟有超过20次FRs的通道数量与癫痫发作频率之间存在线性正相关。虽然对于高FR频率可能存在相关性，但“产生HFOs的组织越多，癫痫发作频率越高”这一假设未得到证实。
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Clin Neurophysiol. 2009 Aug;120(8):1457-64. doi: 10.1016/j.clinph.2009.05.029. Epub 2009 Jul 2.
2
High-frequency oscillations mirror disease activity in patients with epilepsy.高频振荡反映癫痫患者的疾病活动。
Neurology. 2009 Mar 17;72(11):979-86. doi: 10.1212/01.wnl.0000344402.20334.81.
3
Effect of sleep stage on interictal high-frequency oscillations recorded from depth macroelectrodes in patients with focal epilepsy.睡眠阶段对局灶性癫痫患者深部宏观电极记录的发作间期高频振荡的影响。
Epilepsia. 2009 Apr;50(4):617-28. doi: 10.1111/j.1528-1167.2008.01784.x.
4
Spatial localization and time-dependant changes of electrographic high frequency oscillations in human temporal lobe epilepsy.人类颞叶癫痫中脑电高频振荡的空间定位及时变变化
Epilepsia. 2009 Apr;50(4):605-16. doi: 10.1111/j.1528-1167.2008.01761.x. Epub 2008 Aug 20.
5
Epileptogenicity of brain structures in human temporal lobe epilepsy: a quantified study from intracerebral EEG.人类颞叶癫痫中脑结构的致痫性：一项来自脑内脑电图的定量研究
Brain. 2008 Jul;131(Pt 7):1818-30. doi: 10.1093/brain/awn111. Epub 2008 Jun 13.
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Epilepsia. 2008 Nov;49(11):1893-907. doi: 10.1111/j.1528-1167.2008.01656.x. Epub 2008 May 9.
7
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9
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