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Loss of PTEN expression predicts resistance to EGFR-targeted monoclonal antibodies in patients with metastatic colorectal cancer.

作者信息

Mao C, Liao R-Y, Chen Q

出版信息

Br J Cancer. 2010 Mar 2;102(5):940. doi: 10.1038/sj.bjc.6605575. Epub 2010 Feb 16.

DOI:10.1038/sj.bjc.6605575
PMID:20160728
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2833261/
Abstract
摘要

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本文引用的文献

1
PTEN expression and KRAS mutations on primary tumors and metastases in the prediction of benefit from cetuximab plus irinotecan for patients with metastatic colorectal cancer.原发性肿瘤和转移灶中PTEN表达及KRAS突变对转移性结直肠癌患者从西妥昔单抗联合伊立替康治疗中获益的预测作用
J Clin Oncol. 2009 Jun 1;27(16):2622-9. doi: 10.1200/JCO.2008.20.2796. Epub 2009 Apr 27.
2
Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant.原发性结直肠癌及其相关转移部位中表皮生长因子受体（EGFR）和下游蛋白的不同程度失调可能具有临床相关性。
Br J Cancer. 2009 Apr 7;100(7):1087-94. doi: 10.1038/sj.bjc.6604848. Epub 2009 Mar 17.
3
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies.结直肠癌中的PIK3CA突变与对表皮生长因子受体（EGFR）靶向单克隆抗体的临床耐药性相关。
Cancer Res. 2009 Mar 1;69(5):1851-7. doi: 10.1158/0008-5472.CAN-08-2466. Epub 2009 Feb 17.
4
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients.PTEN表达缺失可预测西妥昔单抗对转移性结直肠癌患者的疗效。
Br J Cancer. 2007 Oct 22;97(8):1139-45. doi: 10.1038/sj.bjc.6604009. Epub 2007 Oct 16.