用于触发内容物释放的含可光聚合磷脂脂质体的设计
DESIGN OF LIPOSOMES CONTAINING PHOTOPOLYMERIZABLE PHOSPHOLIPIDS FOR TRIGGERED RELEASE OF CONTENTS.
作者信息
Yavlovich Amichai, Singh Alok, Tarasov Sergey, Capala Jacek, Blumenthal Robert, Puri Anu
机构信息
Membrane Structure and Function Section, Nanobiology Program, Center for Cancer Research, NCI-Frederick, Frederick, MD 21702.
出版信息
J Therm Anal Calorim. 2009 Oct 1;98(1):97-104. doi: 10.1007/s10973-009-0228-8.
Abstract
We describe a novel class of light-triggerable liposomes prepared from a photo-polymerizable phospholipid DC(8,9)PC (1,2- bis (tricosa-10,12-diynoyl)-sn-glycero-3-phosphocholine) and DPPC (1,2-Dipalmitoyl-sn-Glycero-3-Phosphocholine). Exposure to UV (254 nm) radiation for 0-45 minutes at 25 degrees C resulted in photo-polymerization of DC(8,9)PC in these liposomes and the release of an encapsulated fluorescent dye (calcein). Kinetics and extents of calcein release correlated with mol% of DC(8,9)PC in the liposomes. Photopolymerization and calcein release occurred only from DPPC/DC(8,9)PC but not from Egg PC/DC(8,9)PC liposomes. Our data indicate that phase separation and packing of polymerizable lipids in the liposome bilayer are major determinants of photo-activation and triggered contents release.
摘要
我们描述了一类新型的光触发脂质体，它由可光聚合的磷脂DC(8,9)PC（1,2-双（二十三碳-10,12-二炔酰基）-sn-甘油-3-磷酸胆碱）和DPPC（1,2-二棕榈酰-sn-甘油-3-磷酸胆碱）制备而成。在25℃下暴露于紫外线（254nm）辐射0至45分钟，导致这些脂质体中的DC(8,9)PC发生光聚合，并释放出包封的荧光染料（钙黄绿素）。钙黄绿素释放的动力学和程度与脂质体中DC(8,9)PC的摩尔百分比相关。光聚合和钙黄绿素释放仅发生在DPPC/DC(8,9)PC脂质体中，而在Egg PC/DC(8,9)PC脂质体中则不会发生。我们的数据表明，脂质体双层中可聚合脂质的相分离和堆积是光激活和触发内容物释放的主要决定因素。
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