在Sonogashira反应条件下，一种高效的、微波辅助的吲哚一锅法合成
An Efficient, Microwave-Assisted, One-Pot Synthesis of Indoles Under Sonogashira Conditions.
作者信息
Chen Yu, Markina Nataliya A, Larock Richard C
机构信息
Department of Chemistry, Iowa State University, Ames, IA 50011.
出版信息
Tetrahedron. 2009 Oct 31;65(44):8908-8915. doi: 10.1016/j.tet.2009.07.075.
Abstract
A microwave-assisted, one-pot, three-component coupling reaction for the synthesis of indoles has been developed. The reaction is carried out in two steps under standard Sonogashira coupling conditions from an N-substituted/N,N-disubstituted 2-iodoaniline and a terminal alkyne, followed by the addition of acetonitrile and an aryl iodide. A variety of polysubstituted indoles have been prepared in moderate to excellent yields using the present method.
摘要
已开发出一种用于合成吲哚的微波辅助一锅三组分偶联反应。该反应在标准的Sonogashira偶联条件下分两步进行，以N-取代/N,N-二取代的2-碘苯胺和末端炔烃为原料，随后加入乙腈和芳基碘化物。使用本方法已以中等至优异的产率制备了多种多取代吲哚。
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