（-）-前列腺素E₂主要尿代谢物的制备
Preparation of the Major Urinary Metabolite of (-)-Prostaglandin E(2).
作者信息
Taber Douglass F, Gu Peiming
机构信息
Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716.
出版信息
Tetrahedron. 2009 Aug 1;65(31):5904-5907. doi: 10.1016/j.tet.2009.05.059.
Abstract
The best way to measure whole body production of the locally acting hormone prostaglandin E(2) (PGE(2)) is to assess the accumulation of the major urinary metabolite, PGE(2) U (M). A practical preparation of this delicate diacid is described. This synthetic PGE(2)U(M) will enable production of the antibodies that will be used to quantify this key metabolite.
摘要
测量局部作用激素前列腺素E2（PGE2）全身生成量的最佳方法是评估主要尿液代谢产物PGE2 U（M）的蓄积情况。本文描述了这种精细二酸的一种实用制备方法。这种合成的PGE2 U（M）将能够产生用于定量这种关键代谢产物的抗体。
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